The role of obesity in nocturnal heartbur

Withdrawn

• Conditions: nocturnal GERD; nocturnal heartburn; 10017977

• Registration Number: NL-OMON32693
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

- Man and woman > 18 years of age
- Proven nocturnal GERD (pH < 4 during > 3 % of supine position)
- Non-obese subjects: BMI 18.5-24.9 kg/m2
- Obese subjects: BMI > 30 kg/m2

Exclusion Criteria

- Pre-existent esophageal motility disorders
- Proven obstructive sleep apnea with CPAP therapy
- Inability to stop medication that affects the motility of the upper gastrointestinal tract (anti-cholinergic drugs, theophylline, calcium blocking agents, opioids)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The difference in nocturnal reflux pattern (reflux time / 24 h, frequency of<br /><br>reflux episodes, LES pressure) between obese and normal-weight subjects with<br /><br>GERD.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>n.v.t.</p><br>