Comparison of Ultrasound guided intra articular local anaesthetic and steroid injection with ultrasound guided genicular block with local anaesthetic and steroid injection in chronic pain due to Osteoarthritis of knee joint
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 56
- 试验地点
- 1
- 主要终点
- Assessment of pain using NRS score immediately post procedure, 1 week, 1 month and 3 months after the procedure
研究概览
简要总结
This prospective comparative study (ABVIMS & Dr. RML Hospital, 2025–2026) evaluates pain relief in knee osteoarthritis (OA) using two ultrasound-guided techniques with identical drugs: intra-articular injection (IACSI) versus genicular nerve block (GNB).
Fifty-six adults with unilateral OA (Kellgren–Lawrence Grade 3/4) will be randomized (28 per group).
• Group A: Suprapatellar injection of 60 mg triamcinolone + 6 ml 1% lignocaine.
• Group B: GNB with 20 mg triamcinolone + 2 ml 1% lignocaine at three genicular nerve sites.
Patients and assessors are blinded. Primary outcome: pain score (NRS) at immediate, 1-week, 1-month, and 3-month intervals. Secondary outcomes: function (WOMAC) and complications.
Statistical analysis (SPSS) will compare efficacy using t-test/Mann-Whitney and chi-square/Fisher’s tests (p < 0.05).
The study addresses limited direct evidence comparing these interventions and may guide whether an extra-articular GNB can match or exceed traditional intra-articular injections for sustained pain control in chronic knee osteoarthritis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- All
入选标准
- •Adult patients 2.Diagnosed case of Osteoarthritis Knee with Kellegren- Lawrence grade 3 or grade 4.
排除标准
- •Previous history of knee surgery 2.Dislocated knee 3.Any active infection in knee joint 4.Past intraarticular knee injection or any interventional therapy 5.patients on anticoagulants or bleeding diathesis or uncontrolled diabetes 6.Hypersenitivity to steroid or any local anaesthetic.
结局指标
主要结局
Assessment of pain using NRS score immediately post procedure, 1 week, 1 month and 3 months after the procedure
时间窗: Assessment of pain using NRS score immediately post procedure, 1 week, 1 month and 3 months after the procedure
次要结局
- 1. Functionality assessment by WOMAC Score at 1 week, 1 month and 3 months after the procedure(2.Complications(if any) arising out of the procedure)
研究者
Swagatika Biswal
ABVIMS and Dr RML Hospital, New Delhi