Self-consciousness in Dementia

Not Applicable

• Conditions: Alzheimer Disease; Fronto-temporal Lobar Dementia

• Registration Number: NCT01782248
• Lead Sponsor: University Hospital, Strasbourg, France

Brief Summary

The aim of this study is to characterize the deficit in critical components of personal identity (self-consciousness and social cognition) in patients with Alzheimer's disease (AD) and fronto-temporal lobar dementia (FTLD), compared to healthy elderly, combining a neuropsychology and multi-podal neuroimaging study.

We posit that the alteration of some aspects of self-consciousness (autobiographical memory, nosognosia, metacognition) and social cognition (theory of mind and facial) results in personality changes in the patients, primarily due to the alteration of self-consciousness in AD and to social cognition in FTLD.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2012-10-15
• Study First Submitted QC: 2013-01-30
• Study First Posted: 2013-02-01
• Study Start: 2013-03-13
• Status Verified: 2020-09
• Last Update Submitted: 2020-09-02
• Last Update Posted: 2020-09-03
• Primary Completion: 2022-03-12
• Study Completion: 2022-03-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 65

Inclusion Criteria

• AD (McKhann et al, 1984 and Dubois et al, 2007) or FTLD (Neary et al, 1998 or Rascovsky et al, 2011)
• MMSE > or = 18
• Relative avaible

Exclusion Criteria

• Contraindication to MRI
• Major depression
• Other central neurological condition

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Characterize the deficit in critical components of personal identity in patients with Alzheimer's disease (AD) and fronto-temporal lobar dementia (FTLD), compared to healthy elderly, combining a neuropsychology and multi-podal neuroimaging study.	each month for 3 month

Trial Locations

Locations (1)

Hôpitaux Universitaires de Strasbourg; 🇫🇷 Strasbourg, France