A Community Based Study to determine the burden of fever cases with focus on Dengue & Chikungunya infections

Not yet recruiting

Conditions: Health human volunteers will be enrolled into the study and followed up weekly for documenting any episodes of acute fever for investigation and management

Brief Summary: In view of the rising threat of Dengue infections in the country, the incidence needs to be estimated using cohort study design. Various initiatives have been taken up -both by private and public entities for developing novel vaccines for tackling dengue fever for which sero-surveillance is necessary. Thus this study will support these initiatives to understand the burden of the disease in the county .We are proposing this community based prospective cohort study under DBTâ€™s Resource of Indian Vaccine Epidemiology Network (DRIVEN) funded by National Biopharma Mission, Biotechnology Industry Research Assistance Council (BIRAC), Department of Biotechnology India. The proposed study aims to assess the incidence of dengue fever over a period of 1 year. Although the sample size is not powered for other disease indications (Chikungunya, Malaria, Typhoid, Leptospirosis, Scrub typhus), the study will also estimate the incidence of Chikungunya, Malaria, Typhoid, Leptospirosis, Scrub typhus and proportion of asymptomatic infections, secondary infections as well as describe the circulating dengue and Chikungunya serotypes in the study area by lab confirmation of fever cases during the study period of one year. The epidemiological data generated in the study will be useful in designing future vaccine trials, and conducting the trials and their impact assessment.

Recruitment & Eligibility

Inclusion Criteria

1.Study will be carried out in individuals above 2 Years of age.
2.Individuals currently residing and likely to stay till the end of one year in the study area.
3.Consented to participate in both sections of the study (Sero Prevalence and AFI Surveillance) and follow all study procedures.

Exclusion Criteria

Ongoing fever episodes or history of AFI on or within 3 calendar days before enrolment for the cohort.

Primary Outcome Measures

Name	Time	Method
The primary outcome is estimation of the burden of diseases causing acute febrile illness with focus on Dengue & Chikungunya at community level & determine the seasonal variations and the rate of transmission in the incidence of acute febrile illnesses	Baseline and at the end of 12 months

Secondary Outcome Measures

Name	Time	Method
1.The identification of groups who are most vulnerable to Dengue & Chikungunya infection (e.g. age groups, gender, occupation)	2.The sensitivity and specificity of IgG ELISA will be calculated against PRNT (Neutralizing antibodies).

Locations (1): SHARE (Society for Health Allied Research and Education)
🇮🇳
Medchal, TELANGANA, India
SHARE (Society for Health Allied Research and Education)
🇮🇳Medchal, TELANGANA, India
Nitin Desai
Principal investigator
9985820831
nitincdesai@shareindia.org