Effect of Physical Training on Oxygen Uptake and Endothelial Function in Heart Transplant Recipients

Not Applicable

Completed

• Conditions: Endothelial Function; Heart Transplantation; Exercise Capacity
• Interventions: Other: Intensive physical exercise

• Registration Number: NCT01028599
• Lead Sponsor: Rigshospitalet, Denmark

Brief Summary

The purpose of this study is to investigate the effect of physical training on work capacity and vascular function after heart transplantation, cardiac transplant recipients are randomized to 8 weeks of intense physical training or control. Vascular function is measured non-invasively. Effect on the hormones and the immune system is evaluated using blood samples.

Detailed Description

To investigate the effect of physical training on work capacity and vascular function after heart transplantation, cardiac transplant recipients are randomized to 8 weeks of intense physical training or control. Vascular function is measured non-invasively using forearm flow mediated dilatation. Effect on the blood natriuretic peptides and the inflammatory markers is evaluated using blood samples at baseline and after the training or control period.

Study Timeline

• Study Start: 2009-09
• Primary Completion: 2009-12
• Study First Submitted: 2009-12-08
• Study First Submitted QC: 2009-12-08
• Study First Posted: 2009-12-09
• Study Completion: 2010-01
• Status Verified: 2015-10
• Last Update Submitted: 2015-10-26
• Last Update Posted: 2015-10-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Heart transplant recipients > 1 year after transplantation

Exclusion Criteria

• Recent rejection, severe renal dysfunction, graft dysfunction, allograft vasculopathy, cancer, inability to exercise.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Exercise	Intensive physical exercise	-

Primary Outcome Measures

Name	Time	Method
Change in maximal oxygen uptake.	8 weeks

Secondary Outcome Measures

Name	Time	Method
Change inm flow mediated vasodilatation.	8 weeks