Exercise training effects on improving resistance to chemotherapy in patients with breast and gastrointestinal

Phase 2

• Conditions: Condition 1: Breast cancer. Condition 2: colon cancer.; Malignant neoplasm of breast; Malignant neoplasm of colon

• Registration Number: IRCT2016041818745N7
• Lead Sponsor: niversity In Tehran, Iran

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Inclusion criteria consist: 30-60 year-old women with breast and gastrointestinal cancers; detection of the disease during years 94 and 95; during chemotherapy; by obtaining written consent; lack of response to at least one chemotherapy period (treatment response less than 50%; local recurrence of the disease; the ability of doing exercise training.
Exclusion criteria consist: the lack of cardiovascular disease; out of control blood pressure; diabetes; mental illness; infection or immune and endocrine diseases; metastatic disease.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Response to treatment. Timepoint: Destroy of tumor or decrease of tumor size. Method of measurement: CT or MRI.

Secondary Outcome Measures

Name	Time	Method
Vo2 max , quality of life , and p-gp, ABC, P53, P63, P68, BRCA1 and BRCA2, topoisomerase I and II, Her2, and metallothionein, glutathione and superoxide dismutase. Timepoint: before and after the exercise training. Method of measurement: Questionnaire- Patient records- Blood samples- Western blotting- ELISA- Immunohistochemistry- gene expression.