Epidemiological Study of Intestinal Colonization With Staphylococcus Aureus

Completed

• Conditions: Staphylococcus Aureus
• Interventions: Procedure: Nasal and rectal bacterial samples

• Registration Number: NCT02547272
• Lead Sponsor: Centre Hospitalier Universitaire de Saint Etienne

Brief Summary

Nasal colonization with S. aureus is a risk factor for infection with this bacterium. A methodologically well conducted study of S. aureus bacteremia showed that 80% of S. aureus bacteremia with are due to the strain isolated in the nasal level. However, as part of a study coordinated by the CHU of Saint-Etienne, less than 50% of infections in prosthetic orthopedic devices have been linked to nasal carriage . Outside of exogenous infections, intestinal colonization with S. aureus could be an alternative source of endogenous infections with the waning of orthopedic surgery. In the general population, considering that about one third of the subjects were colonized with S. aureus nasal level and 1 in 5 in the intestine However the proportion of exclusive intestinal porting is not well known .

This study will analyze, among ICU patients, porting S. aureus nasal and rectal level. It will better clarify the relationship between nasal and rectal ports and the risk of developing an infection.

Detailed Description

The adult patients hospitalized in intensive care at the University Hospital of Saint-Etienne have a multiresistant bacteria porting screening at the nose and rectum at admission and then once a week. These samples will be carried unchanged way for the study but will also be a research S Aureus

Study Timeline

• Study Start: 2013-02
• Primary Completion: 2013-07
• Study Completion: 2013-07
• Study First Submitted: 2015-09-09
• Study First Submitted QC: 2015-09-09
• Study First Posted: 2015-09-11
• Status Verified: 2016-03
• Last Update Submitted: 2016-03-22
• Last Update Posted: 2016-03-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 400

Inclusion Criteria

• patients hospitalized in intensive care and benefiting from a screening multiresistant bacteria in nasal and rectal level under routine care

Exclusion Criteria

• refusal of the patient's family

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Nasal and rectal samples	Nasal and rectal bacterial samples	ICU patients with nasal and rectal bacterial samples for the presence of S Aureus

Primary Outcome Measures

Name	Time	Method
prevalence of S. aureus colonization at rectal level	1 month	The presence of a colony of S. aureus on one of the samples

Secondary Outcome Measures

Name	Time	Method
S. aureus strains similar to nasal and rectal level	1 month	S. aureus strains similar in molecular typing

Trial Locations

Locations (1)

CHU de Saint-Etienne; 🇫🇷 St Etienne, France