The effect of ketamine and methadon on healthy volunteers with specialfocus on painscore, sedation, ventilatory depression and change of pupildiameter.
- Conditions
- analgesiarespiratory depressionpijnstillinganalgesieademhalingsdepressie
- Registration Number
- NL-OMON20544
- Lead Sponsor
- eiden University Medical Centre (LUMC)
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 48
Inclusion Criteria
48 healthy volunteers of either sex in the range op 18-45 years.
Exclusion Criteria
1. Obesity (BMI>35);
2. Presence of medical disease (heart-,lung-, liver-,kidney-, neurologic disease,diabetes m, pyrosis,diaphragmatic hernia);
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ittle is known on the relative contribution of NMDARand u-opioid receptor systhems in the analgesic and side effect profile of methadone and ketamine, therefore we measure respiration, sedationscore (Visual Analog Score), painscore (Visual Analogue Score) and pupildiameter (pupillometry).
- Secondary Outcome Measures
Name Time Method