The relations between the level of Mu-opioid receptor (µORs) and postoperative analgesic use in patients undergoing septoplasty: a randomized, prospective trial.

As the level of the µ-Opioid receptor (µORs) increased in the study groups, the duration of the second analgesic requirement increased. Patients with a high level of µORs experienced less analgesic need in the post-op period. In this study, we found that the efficacy of opioid analgesic agents was higher and the need for additional analgesics was lower in patients with higher µ-Opioid receptor (µORs) levels. This effect was thought to be increased by antidepressant effect. Opioid analgesics combined with steroids also reduced need for second analgesic agents.