Assessment of asymmetrical innervation of the right and left m. puborectalis as a possible cause of idiopathic incontinence, by using concentric needle electrodes in an electromyography investigation of the pelvic floor muscles.
Phase 2
Completed
- Conditions
- Denervationloss of nerve supply10028302
- Registration Number
- NL-OMON38239
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 50
Inclusion Criteria
The subjects have idiopathic urinary or faecal incontinence problems.
The subjects have an overactive bladder or dysfunctionel voiding.
The subjects are in the age of 5 to 17 years.
The subjects need a cystoscopy.
Exclusion Criteria
When subjects have had bladder neck surgery.
When subjects have severe congenital anomalies of bladder neck and urethra (epispadias, ectopic ureteroceles, exstrofy).
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>There will be tonic activity in the puborectalis muscle when the patient is<br /><br>sedated (low-threshold MUPs), in contrast to skeletal muscles. A difference in<br /><br>muscle activity is demonstrated by the motor unit potential (MUP) count.<br /><br>Besides that there is a prolonged insertion activity in denervated muscles.</p><br>
- Secondary Outcome Measures
Name Time Method <p>The MUP parameters will be compared with the normative values as described in<br /><br>literature. MUP parameters are: amplitude, duration, area, thickness, size<br /><br>index, phases, turns and spike duration. In denervated and reinnervated muscles<br /><br>these values are abnormal. In reinnervated muscles a prolonged wave form of the<br /><br>MUP is seen together with instability of the MUP. After some time the duration<br /><br>of the MUP reverts towards normal while the MUP amplitude increases.<br /><br>Furthermore, it is important to observe whether there is abnormal spontaneous<br /><br>activity on one or both muscles, because this is an indication for a pathology. </p><br>