High dose calcium channel blocker study for essential hypertensio
Not Applicable
- Conditions
- Essential hypertension
- Registration Number
- JPRN-UMIN000011161
- Lead Sponsor
- Kazuomi Kario
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 180
Inclusion Criteria
Not provided
Exclusion Criteria
(1)Secondary hypertension (2)Patients with history of myocardial infarction or cerebral stroke within 6 months (3)Patients with cardiogenic shock (4)Patients with auricular fibrillation (5)Patients with severe liver disorders or kidney disorders (6)Dialysis patients (7)Pregnant, possible to pregnancy, or lactating women (8)Patients with history of sensitivity to the ingredients (9)Any those the investigator or other researchers consider as unsuitable
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 24-hour mean value of blood pressure (ABPM)
- Secondary Outcome Measures
Name Time Method (1)Efficacy: 1. Daytime blood pressure (ABPM) 2. Nocturnal blood pressure (ABPM) 3. Morning blood pressure (ABPM) 4. Achievement ratio to targeted value of blood pressure (set the targeted value as 24-hour mean blood pressure < 130mmHg) 5. Heart rate 6. Home blood pressure 7. Home heart rate 8. NTproBNP 9. High-sensitivity troponin T 10. Blood pressure variation index (ARV, CV, SD, Peak-Trough et al. 11. Urinary albumin excretion (adjust spot urine with creatinine) (2)Safeties: Incidence of adverse events (headache, palpitation, edema et al.)