To see whether measuring blood pressure change correlates with measuring speed & time of flowing of major blood vessels in pts undergoing major surgeries under generl anesthesia on artificial breathing machine that can help in identifying which pts will get benefited frm giving fluids.
- Conditions
- Health Condition 1: null- Adult patients undergoing elective surgeries having major blood loss or fluid shifts requiring cardiac output monitoring under general anaesthesia
- Registration Number
- CTRI/2017/08/009243
- Lead Sponsor
- Tata Memorial Centre
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
1.Adult patients (Age > 18 yrs )
2.Elective surgeries cases having major blood loss or fluid shifts requiring cardiac output monitoring under general anaesthesia
3.Receiving lung ventilation 8 ml/kg PBW using Volume Assist Control mode.
4.With invasive arterial blood pressure monitoring and cardiac output monitoring using Flotrac EV1000
1.Age under 18 years
2.Patient in whom brachial artery could not be identified with certainty viz above elbow amputated patients and patient with known PVD.
3.absence of sinusrhythm,
4.presence of a ventricular assist device
5.Carotid artery stenosis( common carotid artery stenosis greater than 50 %(systolic peak velocity >182 cm/s and/or diastolic velocity >30 cm/s by Doppler ultrasound)-as assessed by clinician from critical care with previous formal training in critical care ultrasound
6.contraindication to the prespecified ventilatory parameters (a period of passive ventilation at tidal volume [Vt] 8 mL/kg of predicted body weight
7.Known heart failure and LVEF < 40%
8.Valvular heart disease
9.Aortic insufficiency
10.Air leakage through chest drains
11.spontaneous respiratory efforts
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To determine whether brachial artery velocity time integral and carotid artery velocity time integral could substitute as an accurate, noninvasive surrogate for Pulse Pressure Variation in predicting fluid responsiveness in patients undergoing major surgeries with controlled mechanical ventilationTimepoint: before and after fluid bolus
- Secondary Outcome Measures
Name Time Method ilTimepoint: Nil