Isotopic Imaging for Prodromal Alzheimer's Disease

Completed

• Conditions: Alzheimer Disease

• Registration Number: NCT01231295
• Lead Sponsor: Centre Hospitalier Universitaire de Nīmes

Brief Summary

The primary objective of this study is to characterize cerebral metabolism modifications using 18F-FDG PET technology and perfusion with 99MTC-ECD SPECT in patients with prodromal Alzheimer's Disease drawn from a high risk population. We also compare PET and SPECT imaging within this framework, and search for optimal diagnostic thresholds.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2010-10-29
• Study First Submitted QC: 2010-10-29
• Study First Posted: 2010-11-01
• Study Start: 2011-02
• Primary Completion: 2016-09
• Study Completion: 2016-09
• Status Verified: 2017-01
• Last Update Submitted: 2017-01-31
• Last Update Posted: 2017-02-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 143

Inclusion Criteria

Not provided

Exclusion Criteria

• Instrumental Activities of Daily Living (IADL): at least two items > 1
• Anticholinesterasic treatments and/or memantin before study inclusion
• major depressive syndrome, according to the Global Depressive Scale
• Known neurodegenerative disease or general disease or major physical problems that could interfere with cognitive functioning and testing
• Pathology that might lead to death in the short term (evolving cancer, non stable cardiopathy, hepatic, renal or respiratory insufficiency)
• contra-indications for MRI, PET or SPECT scans
• not affiliated with a social security regimen

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The difference between AUCs for PET and SPECT imaging	1 month	The difference between the AUCs (area under the curve) for PET and SPECT imaging.

Trial Locations

Locations (25)

CHU de Bordeaux - Groupe Hospitalier Pellegrin; 🇫🇷 Bordeaux, France

CHU d'Amiens - Hôpital Sud; 🇫🇷 Amiens Cedex 1, France

APHP - Hôpital Emile Roux; 🇫🇷 Limeil Brevannes Cedex, France

CHU de Rouen - Hôpital Charles Nicolle; 🇫🇷 Rouen, France

APHP - Hôpital Broca; 🇫🇷 Paris, France

CHRU de Lille - Hôpital Roger Salengro; 🇫🇷 Lille, France

CHU de Nice - Hôpitaux L'Archet 1 et 2; 🇫🇷 Nice, France

CHU de Nîmes - Hôpital Universitaire Carémeau; 🇫🇷 Nîmes Cedex 09, France

APHP - Hôpital Lariboisière; 🇫🇷 Paris, France

APHP - Groupe Hospitalier Pitié-Salpetrière; 🇫🇷 Paris cedex 13, France

CHRU de Toulouse - Hôpital Garonne; 🇫🇷 Toulouse cedex 9, France

CHU de Poitiers; 🇫🇷 Poitiers, France

CHRU de Toulouse - Hôpital Purpan; 🇫🇷 Toulouse Cedex 9, France

APHM - Hôpital La Timone Adultes; 🇫🇷 Marseille cedex 5, France

CHU de Montpellier - Hôpital Gui de Chauliac; 🇫🇷 Montpellier Cedex 5, France

CHU de Nancy - Hôpital Central; 🇫🇷 Nancy, France

CHRU de Strasbourg - Hôpital de Hautepierre; 🇫🇷 Strasbourg, France

CHU d'Angers - Hôtel-Dieu; 🇫🇷 Angers, France

CHU de Besançon - Hôpital Jean Minjoz; 🇫🇷 Besançon, France

APHP - Hôpital Albert Chenevier; 🇫🇷 Creteil Cedex, France

APHP - Hôpital Charles Foix; 🇫🇷 Ivry Sur Seine Cedex, France

CHRU de Lille - Hôpital Claude Huriez; 🇫🇷 Lille, France

CHU de Reims - Hôpital Maison Blanche; 🇫🇷 Reims, France

CHRU de Tours - Hôpital Bretonneau; 🇫🇷 Tours, France

Groupe Hospitalier Paris Saint-Joseph; 🇫🇷 Paris, France