Effect of low copper diet and penicillamine combination on high grade brain glioma
Not Applicable
- Conditions
- Brain tumor.Glioblastoma multiforme unspecified siteC71.9,C72.
- Registration Number
- IRCT2013101415018N1
- Lead Sponsor
- Kamrani charity foundation,Iran Gamma Knife Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
pathologic diagnosis; tumor recurrence; Age equal to or more than 18 years ;KPS equal to or more than 60 (the status of neurological function); informed consent;literacy
Exclusion criteria: Avastin (Bevacizumab)use; reduction serum copper to less than 70 micrograms per deciliter;allergy to penicillin and penicillamine; pregnancy; Lack of adequate hematologic, hepatic and renal function
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Vascular endothelial growth factor. Timepoint: Before and after the intervention. Method of measurement: How to measure: ELISA, scale: micro mEq per liter.;Interleukin-6. Timepoint: Before and after the intervention. Method of measurement: How to measure: ELISA, scale: micro mEq per liter.;Interleukin-8. Timepoint: Before and after the intervention. Method of measurement: How to measure: ELISA, scale: micro mEq per liter.;Tumor Necrosing Factor. Timepoint: Before and after the intervention. Method of measurement: How to measure: ELISA, scale: micro mEq per liter.;Karnovski Performance Score(KPS). Timepoint: Before intervention,one and a half months after the intervention and at the end of intervention. Method of measurement: How to measure: clinical, scale:table.
- Secondary Outcome Measures
Name Time Method Drug complications. Timepoint: During the intervention. Method of measurement: Patient quote and physical exam.;Serum copper. Timepoint: Before intervention,one and a half months after the intervention and at the end of intervention. Method of measurement: How to measure: biochemical, scale: micro gram per deciliter.