Organization of the Cingulate Cortex

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Other: Train; Other: MRI; Other: EEG

• Registration Number: NCT03119870
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

Efficient evaluation and monitoring of actions and outcomes are a key feature of primates' efficient adaptive cognition. Deficits in evaluating one's own actions and their consequences is a key feature of prominent disorders such as obsessive compulsive disorders (OCD), schizophrenia, and anxiety. The Investigators know that these evaluative processes implicate medial structures of the brain that are related both to old limbic functions and to more recently evolved higher executive functions. Brain potentials related to performance monitoring have attracted a lot of interest in cognitive neuroscience but also in the clinical domain because they appear to be altered in different neurological or psychiatric disorders, such as schizophrenia, OCD, or anxiety, and could become biomarkers of pathologies. But the neural sources of these markers are not fully determined and are currently highly debated. In addition, our work suggests that non pathological factors, such as normal morphological cortical variations, could affect those markers. Understanding performance monitoring, acting directly on medial cortex, or using electrophysiological markers in clinic are thus currently problematic and challenging. This is mostly because structure-function relationships in the medial wall are ill defined for historical, conceptual, and methodological reasons. Importantly, although individual variability of brain morphology impedes precise assessment of structure function relationships, this variability is almost never taken into account. EEG-Feedback aims to resolve these issues by evaluating the consequences of individual variability in cingulate cortex morphology on 1) surface EEG markers of feedback monitoring and 2) functional connectivity patterns thanks to resting-state fMRI.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-01-09
• Primary Completion: 2013-09-06
• Study First Submitted: 2017-03-09
• Study First Submitted QC: 2017-04-13
• Study First Posted: 2017-04-19
• Status Verified: 2017-07
• Study Completion: 2017-07-04
• Last Update Submitted: 2017-07-06
• Last Update Posted: 2017-07-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 31

Inclusion Criteria

• being able to provide a writen consent form
• having a social insurance
• have a normal vision (with or without corrections)
• Right-handed

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Exclusion Criteria

• Subjects with MRI contraindications (e.g. pacemaker, claustrophobia, metal in the body, etc...).
• Subjects must be willing to be advise in case of discovery of brain abnormality.
• No history of known neurological or psychiatric illness
• Pregnant or nursing women
• Persons under guardianship, curatorship or any other administrative or judicial measure of deprivation of rights or liberty, as well as legal persons protected by law

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
1	Train	Each subject will conduct 3 sessions, i.e. a training session, an anatomical MRI session and an EEG session. The first session will be to train the subject to carry out the different behavioral tasks that he will then have to perform during the session of EEG.
1	MRI	Each subject will conduct 3 sessions, i.e. a training session, an anatomical MRI session and an EEG session. The first session will be to train the subject to carry out the different behavioral tasks that he will then have to perform during the session of EEG.
1	EEG	Each subject will conduct 3 sessions, i.e. a training session, an anatomical MRI session and an EEG session. The first session will be to train the subject to carry out the different behavioral tasks that he will then have to perform during the session of EEG.

Primary Outcome Measures

Name	Time	Method
Resting state fMRI data	3 years	BOLD signal will be analyzed in the low frequency band (0.1-0.01Hz). Images must be not too much distorted to allow data analysis. As such, if a subject moved too much (translation\>10mm; rotation\>5°) the corresponding data will be excluded from the analysis.
Behavioral data in the EEG experiment	3 years	Performance in the task will be assessed. If performance in the task is \<80%, subjects will be excluded in the final analysis.
EEG data	3 years	If recordings are too noisy (if only \<30% of trials survive the denoising process), subject will be excluded from final analysis.

Trial Locations

Locations (1)

Hospices Civils de Lyon, Groupement Hospitalier Est; 🇫🇷 Bron, France