Meta-analysis of Stannous Fluoride and the Effects on Dental Plaque

Completed

• Conditions: Dental Plaque
• Interventions: Drug: Positive control dentifrice; Drug: Negative control dentifrice; Drug: Stannous fluoride dentifrice

• Registration Number: NCT04006483
• Lead Sponsor: Procter and Gamble

Brief Summary

The aim of this 18 study analysis was to compare the effect of bioavailable stannous fluoride (SnF2) dentifrices when used up to 3 months on dental plaque relative to a positive or negative control dentifrice.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-01-08
• Primary Completion: 2018-11-30
• Study Completion: 2018-11-30
• Study First Submitted: 2019-07-01
• Study First Submitted QC: 2019-07-01
• Study First Posted: 2019-07-05
• Status Verified: 2023-11
• Last Update Submitted: 2023-11-14
• Last Update Posted: 2023-11-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 2359

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Positive control dentifrice	Positive control dentifrice	Twice daily brushing
Negative control dentifrice	Negative control dentifrice	Twice daily brushing
Stannous Fluoride Dentifrice	Stannous fluoride dentifrice	Twice daily brushing

Primary Outcome Measures

Name	Time	Method
Dental Plaque Scores	Up to 12 weeks	Change from baseline as measured by mean plaque score reduction from baseline (via Quigley-Hein, Turesky Modification Index or Rustogi Modification of the Navy Plaque index).

Trial Locations

Locations (1)

Multiple P&G Investigation Clinical Sites; 🇺🇸 Cincinnati, Ohio, United States