Intake Duration Effects of Blackcurrant on Cardiovascular and Metabolic Responses

Not Applicable

Completed

• Conditions: no Conditions

• Registration Number: NCT05067062
• Lead Sponsor: University of Chichester

Brief Summary

Study will examine the metabolic, physiological and cardiovascular changes by intake of New Zealand blackcurrant extract at rest and during moderate-intensity treadmill walking in healthy males.

Detailed Description

The investigators will examine effects of acute intake, intermittent intake and chronic intake of New Zealand blackcurrant extract using indirect calorimetry and hemodynamic measurements.

Study Timeline

• Study Start: 2017-09-01
• Primary Completion: 2018-09-01
• Study Completion: 2018-09-01
• Study First Submitted: 2021-09-10
• Status Verified: 2021-10
• Study First Submitted QC: 2021-10-01
• Last Update Submitted: 2021-10-01
• Study First Posted: 2021-10-04
• Last Update Posted: 2021-10-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 15

Inclusion Criteria

• Healthy
• Non-smokers
• Not taking any supplements
• No known allergy to berries or berry products

Exclusion Criteria

• Sedentary
• Known high blood pressure
• Smoking
• On medication

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Changes in heart rate from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract	baseline, acute, one week and two weeks	The investigators will use a beat-to-beat blood pressure monitoring system (Portapres® Model 2, Finapres Medical Systems BV, Amsterdam, The Netherlands). The Portapres® is a beat-to-beat finger pressure analyser that allows the non-invasive continuous measurement of hemodynamic parameters. The finger cuff will be positioned around the same finger of the left hand for each testing. All measurements will be taken in rest and during moderate-intensity exercise.; Heart rate will be measured in beats/min.
Changes in total peripheral resistance from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract	baseline, acute, one week and two weeks	The investigators will use a beat-to-beat blood pressure monitoring system (Portapres® Model 2, Finapres Medical Systems BV, Amsterdam, The Netherlands). The Portapres® is a beat-to-beat finger pressure analyser that allows the non-invasive continuous measurement of hemodynamic parameters. The finger cuff will be positioned around the same finger of the left hand for each testing. All measurements will be taken in rest and during moderate-intensity exercise.; Total peripheral resistance will be measured in (mmHg·min)/L
Changes in stroke volume from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract	baseline, acute, one week and two weeks	The investigators will use a beat-to-beat blood pressure monitoring system (Portapres® Model 2, Finapres Medical Systems BV, Amsterdam, The Netherlands). The Portapres® is a beat-to-beat finger pressure analyser that allows the non-invasive continuous measurement of hemodynamic parameters. The finger cuff will be positioned around the same finger of the left hand for each testing. All measurements will be taken in rest and during moderate-intensity exercise.; Stroke volume will be measured in mL.
Changes in cardiac output from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract	baseline, acute, one week and two weeks	The investigators will use a beat-to-beat blood pressure monitoring system (Portapres® Model 2, Finapres Medical Systems BV, Amsterdam, The Netherlands). The Portapres® is a beat-to-beat finger pressure analyser that allows the non-invasive continuous measurement of hemodynamic parameters. The finger cuff will be positioned around the same finger of the left hand for each testing. All measurements will be taken in rest and during moderate-intensity exercise.; Cardiac output will be measured in L/min.
Changes in blood pressure from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract	baseline, acute, one week and two weeks	The investigators will use a beat-to-beat blood pressure monitoring system (Portapres® Model 2, Finapres Medical Systems BV, Amsterdam, The Netherlands). The Portapres® is a beat-to-beat finger pressure analyser that allows the non-invasive continuous measurement of hemodynamic parameters. The finger cuff will be positioned around the same finger of the left hand for each testing. All measurements will be taken in rest and during moderate-intensity exercise.; Systolic, diastolic and mean arterial blood pressure will be measured in mmHg.

Secondary Outcome Measures

Name	Time	Method
Changes in respiratory exchange ratio from baseline with acute intake, one week and two weeks intake.	baseline, acute, one week and two weeks	The investigators will use Douglas bags to collect expired air. Indirect calorimetry techniques will be used to measured oxygen consumption and carbon dioxide production and allow quantification of carbohydrate and fat oxidation in rest and during moderate-intensity treadmill walking.; Respiratory exchange ratio is unitless and calculated from the ratio of carbon dioxide production and oxygen consumption.
Changes in oxygen consumption from baseline with acute intake, one week and two weeks intake.	baseline, acute, one week and two weeks	The investigators will use Douglas bags to collect expired air. Indirect calorimetry techniques will be used to measured oxygen consumption and carbon dioxide production and allow quantification of carbohydrate and fat oxidation in rest and during moderate-intensity treadmill walking.; Oxygen consumption will be measured in L/min
Changes in fat oxidation from baseline with acute intake, one week and two weeks intake.	baseline, acute, one week and two weeks	The investigators will use Douglas bags to collect expired air. Indirect calorimetry techniques will be used to measured oxygen consumption and carbon dioxide production and allow quantification of carbohydrate and fat oxidation in rest and during moderate-intensity treadmill walking.; Fat oxidation is calculated using carbon dioxide production and oxygen consumption and expressed in g/min.
Changes in carbon dioxide production from baseline with acute intake, one week and two weeks intake.	baseline, acute, one week and two weeks	The investigators will use Douglas bags to collect expired air. Indirect calorimetry techniques will be used to measured oxygen consumption and carbon dioxide production and allow quantification of carbohydrate and fat oxidation in rest and during moderate-intensity treadmill walking.; Carbon dioxide production will be measured in L/min.
Changes in carbohydrate oxidation from baseline with acute intake, one week and two weeks intake.	baseline, acute, one week and two weeks	The investigators will use Douglas bags to collect expired air. Indirect calorimetry techniques will be used to measured oxygen consumption and carbon dioxide production and allow quantification of carbohydrate and fat oxidation in rest and during moderate-intensity treadmill walking.; Carbohydrate oxidation is calculated using carbon dioxide production and oxygen consumption and expressed in g/min.

Trial Locations

Locations (1)

Mark Willems; 🇬🇧 Chichester, West Sussex, United Kingdom