Detection and kinetics of IL-38 positive cells in induced sputum in atopic mild adult asthmatics after allergen challenge
Not Applicable
- Conditions
- Atopic mild adult asthma
- Registration Number
- JPRN-UMIN000033420
- Lead Sponsor
- Department of medicine, Kurume University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up continuing
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Not provided
Exclusion Criteria
1. Difficulty expectoration of induced sputum 2. Presence of any other moderate and severe comorbidities 3. Current or ex-smokers 4. participants who have judged that research directors and researchers are inappropriate as research subjects 5. Nursing and pregnancy
Study & Design
- Study Type
- Others,meta-analysis etc
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary endpoint is to investigate the correlation frequency of IL-38 positive cells per macrophage or monocytes in induced sputum and airway inflammation, hyperresponsiveness on methacholine, and asthmatic response after allergen challenge in atopic mild adult asthmatics.
- Secondary Outcome Measures
Name Time Method Secondary endpoint is investigate the correlation frequency of IL-38 positive cells per macrophage or monocytes in induced sputum and peripheral blood in atopic mild adult asthmatics. We investigate whether frequency of IL-38 positive cells per macrophage or monocytes induced sputum and peripheral blood will be able to usefulness to evaluate the pathogenesis and severity of asthma as a biomarker.