Interleukin-38 Levels in Individuals With Periodontitis

Not yet recruiting

• Conditions: Gingivitis; Periodontitis; Healthy
• Interventions: Other: Saliva; Other: gingival crevicular fluid

• Registration Number: NCT05568290
• Lead Sponsor: Saglik Bilimleri Universitesi

Brief Summary

Interleukin (IL)-38 is the newest member of the IL-1 family. It can bind to receptors through various pathways and regulate the formation and function of inflammatory cytokines. Periodontitis is a chronic inflammatory disease that can start with localized inflammatory reactions created by the supporting tissues surrounding the teeth against microorganisms and then result in loss of teeth. The aim of this study is to compare the IL-38, IL-1β and IL-10 levels of healthy and periodontitis individuals.

Detailed Description

Periodontitis is a destructive chronic inflammatory disease that can start with localized inflammatory reactions created by the supporting tissues surrounding the teeth against microorganisms and then result in loss of teeth. More than any other cytokine family, the interleukin (IL)-1 family (IL-1α, IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ, IL-1Ra, IL-36Ra, IL-37, IL-38) includes key signaling molecules that trigger and perpetuate periodontal inflammation.

Interleukine -1β ( IL-1β ) levels are associated with periodontal destruction in the pathogenesis of periodontal disease. Interleukine-10 (IL-10) has been reported to decrease periodontal disease progression rate.

Gingival crevicular fluid shows the cellular response in the periodontium. The most important host-related ingredients are inflammatory markers, including cytokines, enzymes, and interleukins. Saliva analysis is used in the diagnosis of systemic conditions as well as in the diagnosis of oral pathologies.

In recent studies, IL-38 expression has been reported to be abnormal (abnormal) in chronic inflammatory diseases, especially in rheumatoid diseases such as systemic lupus erythematosus, rheumatoid arthritis, psoriasis, and inflammatory bowel disease. Therefore, this relationship of this inflammatory cytokine with chronic inflammatory diseases draws attention to the regulatory effect of IL-38 in these diseases. The aim of this study is to compare the IL-38, IL-1β and IL-10 levels of healthy and periodontitis individuals.

Study Timeline

• Status Verified: 2022-09
• Study First Submitted: 2022-09-10
• Study Start: 2022-09-30
• Study First Submitted QC: 2022-09-30
• Last Update Submitted: 2022-09-30
• Study First Posted: 2022-10-05
• Last Update Posted: 2022-10-05
• Primary Completion: 2022-11-10
• Study Completion: 2022-12-10

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

• systemically healthy individuals who does not have a disease under treatment,
• individuals without regular systemic medication

Exclusion Criteria

• smoking
• receiving periodontal treatment in the last 6 months
• pregnancy
• lactation

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Healthy	Saliva	Individuals with Periodontally Healthy
Healthy	gingival crevicular fluid	Individuals with Periodontally Healthy
Periodontitis	Saliva	Individuals with Periodontitis
Gingivitis	Saliva	Individuals with Gingival Inflammation
Gingivitis	gingival crevicular fluid	Individuals with Gingival Inflammation
Periodontitis	gingival crevicular fluid	Individuals with Periodontitis

Primary Outcome Measures

Name	Time	Method
IL-38 levels	initial examination, baseline	saliva and DOS levels
IL-1β levels	initial examination, baseline	saliva and DOS levels
IL-10 levels	initial examination, baseline	saliva and DOS levels

Secondary Outcome Measures

Name	Time	Method
Probing Depth	initial examination, baseline	millimeter
Plaque Index	initial examination, baseline	Silness-Löe
Bleeding on Probe	initial examination, baseline	Ainamo\&Bay

Trial Locations

Locations (1)

Saglik Bilimleri Universitesi; 🇹🇷 İstanbul, Turkey