Structural reserve predict upper limb function outcome after stroke

Phase 1

Recruiting

• Conditions: stroke

• Registration Number: ITMCTR1900002619
• Lead Sponsor: Ethics Committee in Yueyang Hospital of Integrated Traditional Chinese and Western Medicine affiliated to Shanghai University of Traditional Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

(1) Patients meet the diagnostic criteria of cerebral infarction with integrated Chinese and western medicine;
(2) Patients diagnosed with cerebral infarction with upper limb movement dysfunction by MRI or CT;
(3) Patients aged 30 to 80 years old male and female;
(4) No limitation on the degree of limb dysfunction within 1 week after the first onset of disease course;
(5) Clear consciousness without obvious aphasia or cognitive dysfunction;
(6) No limb deformity, motor dysfunction or sensory dysfunction before onset;
(7) Without skull defect or other physical diseases, and can withstand the detection for 1h;
(8) Sign informed consent.

Exclusion Criteria

(1) Patients with subarachnoid hemorrhage, cerebral embolism, lacunar cerebral infarction and cerebral trauma, who have serious systemic diseases such as cardiopulmonary diseases and cannot tolerate rehabilitation treatment;
(2) Patients with more than two or more cerebral infarction, or with cognitive, verbal, psychological, mental, visual and auditory disorders;
(3) Contraindication of transcranial magnetic stimulation (TMS) and magnetic resonance (MRI) examination, such as pacemaker, metal implant, etc., in pregnant or lactating women;
(4) Patients with motor dysfunction before onset should apply drugs (antiepileptic drugs, sedative and hypnotic drugs, etc.) to change the excitability of cerebral cortex;
(5) Pregnant or lactating women.

Study & Design

• Study Type: Diagnostic test
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Fugl-Meyer assessment of upper extremity, FMA-UE (Fugl-Meyer assessment of upper extremity, FMA-UE);

Secondary Outcome Measures

Name	Time	Method
ational institutes of health stroke scale;Box and block test, BBT;The Functional Independence Measure (FIM);