Sex differences and the Perception of Upright under different Gravity loads – implications for spaceflight
- Conditions
- Healthy volunteers
- Registration Number
- DRKS00030208
- Lead Sponsor
- DLR Deutsches Zentrum für Luft- und Raumfahrt Institut für Luft- und Raumfahrtmedizin
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 44
Male and female healthy volunteers between the ages of 20 and 50 years with
A body mass index (BMI) of 20-26 kg/m2 and a height of 160-188 cm
- No competitive athletes
- Subjects willing and able to participate in the entire study
- Successful completion of the inclusion examination
- Present informed consent at the beginning of the study
- Drug or alcohol abuse (regular consumption of more than 20 - 30 g alcohol/day)
- Heavy smoking
- Obesity (BMI > 30)
- Pregnancy (women)
- Diabetes mellitus
- Rheumatic disease
- Muscle or joint diseases
- Laser eye surgery
- Herniated intervertebral disc
- Taking psychotropic drugs and possibly other medications that may affect the experiments
influence the experiments
- claustrophobia
- Heart disease or wearer of a pacemaker
- Hypertension (values above 140/90 mmHg) or hypotension (values below 90/60 mmHg)
- Pronounced orthostatic intolerance or vestibular balance disorders
(kinetosis)
- Renal disease (deviations from normal values for creatinine in plasma, normal value
creatinine < 1.20 mg/dl *)
- Thyroid dysfunction (deviations from normal values for TSH in plasma, normal values TSH 0.27 -4.20 mU/l*) (only in the case of anamnestic suspicion of dysfunction is a
laboratory examination)
- Anemia ( < Hb as normal values, normal value Hb men: 13.5 to 17.5 g/dl; normal values for
women: 12.0 to 15.7 g/dl) *
- Chronic back pain
- Any other condition that, in the opinion of the investigator, makes the subject unsuitable for inclusion in
for inclusion in the study
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary Objective:<br>To explore the effects of different strengths of gravitational stimuli on the perception of upright and vertical as a function of sex, and thereby improve our understanding of orientation perception in humans.
- Secondary Outcome Measures
Name Time Method secondary objectives:<br>(a) To explore sex differences in the influence of Earth's constant gravity on the effects of centrifugal force with respect to perception.<br>b) To explore sex differences in the influence of otolith features on the perception of vertical.<br>