Expanding Live Donor Kidney Transplantation Through Advocacy Training and Social Media

Not Applicable

Active, not recruiting

• Conditions: Kidney Diseases; Kidney Failure

• Registration Number: NCT03099434
• Lead Sponsor: Johns Hopkins University

Brief Summary

This pilot study will be a clinical trial to test the feasibility and effectiveness of an educational intervention and a mobile health intervention in adults with end stage renal disease (ESRD) who have not yet identified a potential live donor.

Detailed Description

Transplant candidates are hesitant to discuss their illness and the difficulties associated with dialysis, and are therefore reluctant to pursue live donor kidney transplant (LDKT). The investigators will conduct a prospective 3-arm randomized controlled trial with two novel interventions to increase live donation. Arm 1 includes LDC program and the Facebook app, Arm 2 includes just the Facebook app, and Arm 3 includes standard of care. The investigators primary objective is to demonstrate the the effectiveness of these interventions in increasing live donor transplantation rates for candidates with no prior potential live donor.

Study Timeline

• Study First Submitted: 2017-03-28
• Study First Submitted QC: 2017-03-28
• Study Start: 2017-04-01
• Study First Posted: 2017-04-04
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-16
• Last Update Posted: 2025-04-20
• Primary Completion: 2025-12-07
• Study Completion: 2025-12-07

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 775

Inclusion Criteria

• Kidney transplant candidates aged≥18 added to the waitlist in the last year with no potential live donors are eligible.
• If there is an individual willing to donate, but the candidate is unwilling to consider this option or this particular individual, the candidate is eligible for the trial and may still benefit from identification of new donors or increased comfort accepting donation from others.
• Participants at Johns Hopkins University or University of Alabama must speak English. Participants at Northwestern University must speak English or Spanish.

Exclusion Criteria

• Candidates with live donors currently under evaluation for donation will be excluded.
• Those with a previous kidney transplant will be excluded

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Primary Outcome Measures

Name	Time	Method
Live donor kidney transplantation	within 1 year of enrollment	Live donor kidney transplantation within one year of enrollment into the study will be the primary outcome and will be collected/identified through electronic medical record system.

Secondary Outcome Measures

Name	Time	Method
Live Donor Inquiries	within 1 year of enrollment	Live Donor Inquiries on behalf of candidates will be the secondary outcome and will be collected/identified through electronic medical record system.
knowledge of live donation	within 6 months of enrollment	knowledge of live donation of transplant candidates will be collected during the survey.
comfort initiating conversations	within 6 months of enrollment	comfort initiating conversations with others about live donation will be collected during the survey.

Trial Locations

Locations (2)

Northwestern University; 🇺🇸 Evanston, Illinois, United States

Johns Hopkins University; 🇺🇸 Baltimore, Maryland, United States