Study on common risk cytokine genes for periodontitis, diabetes mellitus, and rheumatoid arthritis
- Conditions
- Periodontitis, Diabetes mellitus, Rheumatoid arthritis
- Registration Number
- JPRN-UMIN000013751
- Lead Sponsor
- Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences
- Brief Summary
A total of 17 candidate single nucleotide polymorphisms were assessed in 185 patients with RA and chronic periodontitis (CP), 149 patients with type 2 DM and CP, 251 patients with CP, and 130 systemically and periodontally healthy controls from a cohort of Japanese adults. The results indicated that the potassium voltage-gated channel KQT-like subfamily, member 1 (KCNQ1) rs2237892 and the peptidylarginine deiminase type 4 (PADI4)_104 rs1748033 polymorphisms were significantly associated with the comorbidity of RA and CP. Additionally, a trend toward increase was shown in the serum levels of anti-cyclic citrullinated peptide immunoglobulin G in the patients with RA and CP as compared to those with RA only. These results suggest that the KCNQ1 and possibly the PADI4_104 may constitute a shared risk gene for RA and CP in Japanese adults.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 800
Not provided
1. Individuals with severe systemic diseases 2. Individuals who are considered not eligible for the present study due to any reasons by the investigators.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Genotype and allele frequencies of cytokines and their related molecules
- Secondary Outcome Measures
Name Time Method Clinical and blood data on systemic and periodontal diseases