changed right heart volumes and function following diuretic withdrawal in pulmonary hypertensio

Recruiting

• Conditions: pulmonary hypertension; right heart failure; 10082206; 10037454

• Registration Number: NL-OMON51476
• Lead Sponsor: Amsterdam UMC

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 17

Inclusion Criteria

- Diagnosed with idiopathic PAH, hereditary PAH, drug- and toxins induced PAH
or CTEPH,
according to ESC/ERS pulmonary hypertension guidelines
- Minimal dosage of 40mg furosemide or 1mg bumetanide a day
- NYHA classification II
- Age >=18 and <=80 years
- Able to understand and willing to sign the Informed Consent Form

Exclusion Criteria

- Pregnant subjects
- Inability to provide informed consent
- Change in PAH specific therapy within 3 months before diuretic withdrawal
- Change in (dose of) any other medication
- Hospitalized for acute decompensation within one year before diuretic
withdrawal
- One or more of the following co-morbidities:, uncontrolled systemic
hypertension (>140/90
mmHg) , renal failure (eGFR <30), recent diagnosis of pulmonary
embolism (within 6 months).
- Contraindication for CMR imaging:
o Claustrophobia
o Implanted cardiac defibrillator or pacemaker
o Cochlear implant
- PH of any cause other than permitted in the entry criteria
- Known history of noncompliance considering therapies

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Volumes: Right atrial end reservoir volume, right atrial volume at end active<br /><br>emptying, right atrial volume at end passive emptying, right ventricular end<br /><br>diastolic volume (RVEDV) (ml), right ventricular end systolic volume (RVESV)<br /><br>(ml)<br /><br>Function: Right atrial reservoir volume, right atrial passive emptying volume,<br /><br>right atrial active emptying volume, right ventricular ejection fraction (RVEF)<br /><br>(%)<br /><br>Contractility: right atrial and right ventricular strain, NT-pro BNP levels</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Other study parameters: bodyweight, 6-minute walking distance, potassium,<br /><br>sodium, creatinine, stroke volume, flow</p><br>