An observational trial to study the effect of fluid accumulation on acute confusional state in patients admitted to the intensive care unit(ICU) with severe infection using CAM-ICU score and a non-ivasive monitor called functional near-infrared spectroscopy (fNIRS) for forebrain mapping.
- Conditions
- Health Condition 1: B968- Other specified bacterial agents as the cause of diseases classified elsewhere
- Registration Number
- CTRI/2024/02/062440
- Lead Sponsor
- AIIMS
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Admitted to the ICU within 24 hours of having been diagnosed with septic shock.
Defined by Sepsis-3 consensus guidelines as a suspected or confirmed source of infection with Sequential organ failure assessment (SOFA) more than or equal to 2 and shock.
Shock is defined as hypotension requiring persistent vasopressor therapy to maintain mean arterial pressure (MAP) of more than 65 mmHg and serum lactate levels greater than 2 mmol per L despite adequate initial fluid resuscitation (at least 30ml per kg of IBW).
Patients on short term mechanical ventilation less than 48 hours.
A pre-ICU diagnosis of cognitive dysfunction as indicated by their medical records on admission, or a primary central nervous system diagnosis like cerebrovascular accident, meningitis, seizure disorder, psychiatric disorder, hypoxic encephalopathy post cardiac arrest.
Death before assessment of ICU-delirium within 3 days of ICU admission.
Life-threatening bleeding, the presence of hemorrhagic shock, as judged by research or treating clinicians.
Burns, Pregnancy.
Referral from or treated at other healthcare facilities.
Patients with a likely extracerebral source of serum S100B elevation (e.g., severe disabling neuromuscular disorders, severe burns, advanced malignancy, polytrauma, and chronic renal failure).
Readmission to ICU.
Withdrawal of consent.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method