Metabolomics in high performance sports: effects of endurance- and strength-specific stimuli on the metabolic profile of elite athletes

Not Applicable

Recruiting

Conditions: Healthy athletes and non-athletes

Registration Number: DRKS00015511

Lead Sponsor: niversitätsklinikum Heidelberg, Innere Medizin VII: Sportmedizin

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Male

Target Recruitment: 32

Inclusion Criteria

Endurance-trained athletes: national and regional high performance athletes, VO2max > 60ml/kg/min, several years of running experience and participation in national and international competitions.

Strength-trained athletes: national and regional high performance athletes, several years of strength training experience or participation in national or international competitions.

Sedentary controls: no regular training activities (< 2x/wk physically active, e.g. driving short distances with a bike, garden works, recreational swimming).

Exclusion Criteria

- minority
- incapacity to consent
- diseases (abnormalities) of the musculoskeletal system such as osteoarthritis, spondylarthrosis, joint or spinal deformity
- cardiovascular diseases (e.g. hypertension, coronary heart disease, haemodynamically relevant valve viability, severe cardiac arrhythmia)
- any acute or chronic disease (e.g. infectious diseases)
- disturbance of coagulation activity
- anamnestic information on muscle disease
- regular medication, in particular non-steroidal anti-inflammatory drugs
- intake of food supplements, in particular creatine, carbohydrate, ß-alanine

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes of the metabolic profile, which will be explained by the concentration and composition or change of the metabolites. Effects between the groups (i) endurance- and strength-trained athletes, as well as between the two groups of athletes and the sedentarycontrols will be investigates as well as (ii) acute exercise-induced effects and longitudinal changes over the training year (= between timepoint 1, timepoint 2 and timepoint 3).<br><br>Measurements: Detection of metabolites using GC/MS in venous and capillary blood samples at rest and after a specific exercise test (treadmill test and threshold test or strength test) at three time points in the course of a training year. <br>

Secondary Outcome Measures