Acute Effects of Moderate Versus High Intensity Exercise on Insulin Sensitivity in Pregnant Women With and Without Gestational Diabetes Mellitus
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 9
- 试验地点
- 1
- 主要终点
- insulin sensitivity
研究概览
简要总结
Exercise training is recognized as effective in preventing and treating many chronic metabolic disorders (1), and long-term exercise programmes have similar effects on glucose control as long-term drug or insulin therapy in type 2 diabetic patients (2). The precise intensity and volume of aerobic exercise needed to produce the most wanted effects on targeted risk factors for subjects at risk of/with established type 2 diabetes, is still uncertain. In this study the investigators will investigate the acute effects of a single bout of moderate versus high intensity exercise on insulin sensitivity in pregnant women with and without gestational diabetes mellitus (GDM). The investigators think that very short bouts of high intensity exercise can be a way to reduce blood glucose in these women.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Gestational diabetes mellitus or normal glucose tolerance
- •able to exercise
排除标准
- 未提供
研究组 & 干预措施
Moderate exercise
Moderate intensity exercise training on bike
干预措施: exercise (Behavioral)
No exercise
No exercise, resting in the lab
High intensity exercise
High intensity, short duration exercise on bike
干预措施: exercise (Behavioral)
结局指标
主要结局
insulin sensitivity
时间窗: 1 day
insulin sensitivity index, as described by Matsuda and DeFronzo. This calculation uses the fasting plasma glucose and plasma insulin, and the average plasma glucose and insulin values over the 30, 60, 90, and 120 minutes after an oral glucose tolerance test (OGTT), and is calculated as:. 10 000/√\[fasting glucose x fasting insulin) x (mean glucose during OGTT x mean insulin during OGTT)\]. We will use a carbohydrate rich meal instead of a classic oral glucose tolerance test with glucose in water.
次要结局
未报告次要终点