Acute Effects of Moderate Versus High Intensity Exercise on Insulin Sensitivity in Pregnant Women With and Without Gestational Diabetes Mellitus
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Diabetes, Gestational
- Sponsor
- Norwegian University of Science and Technology
- Enrollment
- 9
- Locations
- 1
- Primary Endpoint
- insulin sensitivity
- Status
- Terminated
- Last Updated
- 8 years ago
Overview
Brief Summary
Exercise training is recognized as effective in preventing and treating many chronic metabolic disorders (1), and long-term exercise programmes have similar effects on glucose control as long-term drug or insulin therapy in type 2 diabetic patients (2). The precise intensity and volume of aerobic exercise needed to produce the most wanted effects on targeted risk factors for subjects at risk of/with established type 2 diabetes, is still uncertain. In this study the investigators will investigate the acute effects of a single bout of moderate versus high intensity exercise on insulin sensitivity in pregnant women with and without gestational diabetes mellitus (GDM). The investigators think that very short bouts of high intensity exercise can be a way to reduce blood glucose in these women.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Gestational diabetes mellitus or normal glucose tolerance
- •able to exercise
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
insulin sensitivity
Time Frame: 1 day
insulin sensitivity index, as described by Matsuda and DeFronzo. This calculation uses the fasting plasma glucose and plasma insulin, and the average plasma glucose and insulin values over the 30, 60, 90, and 120 minutes after an oral glucose tolerance test (OGTT), and is calculated as:. 10 000/√\[fasting glucose x fasting insulin) x (mean glucose during OGTT x mean insulin during OGTT)\]. We will use a carbohydrate rich meal instead of a classic oral glucose tolerance test with glucose in water.