Delirium in Acute Neurocritical Patient; Comparative Efficacy of Dexmedetomidine vs. Antipsychotics (Quetiapine and Haloperidol)

Not Applicable

Recruiting

• Conditions: Mental and behavioral disorders

• Registration Number: KCT0005367
• Lead Sponsor: Asan Medical Center

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 7 September 2020
• Study Completion: 2022-07-01

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 102

Inclusion Criteria

1.Diagnosis of delirium using Korean version of CAM-ICU or by intensivists using Intensive Care Delirium Screening checklist (ICDSC)
2.Age =18 years and = 90 years
3.Glasgow Coma Score (GCS): 9-15
4.Operation or non-operation cases
5.Expected ICU stay > 48 hours

Exclusion Criteria

6.Safety concerns with drug administration: Heart rate <50 beats/minute, known preoperative left ventricular ejection fraction less than 30%, 2° or greater AV block in the absence of a pacemaker, sick sinus syndrome, torsades de pointes, prolonged corrected QT (> 550 ms) from the baseline EKG
7.History of severe dementia, schizophrenia, Parkinsonism, or myasthenia gravis
8.Current treatment with dexmedetomidine or clonidine
9.Dexmedetomidine or antipsychotics (quetiapine or haloperidol) allergic history
10.Post-anoxic coma; status epilepticus without underlying brain injury; central nervous system (CNS) infections (community-acquired; hospital-acquired; ventriculitis; post-operative)
11.History of hepatic encephalopathy or end stage liver disease (Child- Pugh Class B or C)
12.Pregnancy or Nephrotic syndrome diagnosed patient
13.Brain death or imminent death (within 24 hours)
14.DNR (do not resuscitate) orders

Study & Design

• Study Type: Interventional Study
• Study Design: Not specified