Delirium in Acute Neurocritical Patient; Comparative Efficacy of Dexmedetomidine vs. Antipsychotics (Quetiapine and Haloperidol)

Asan Medical Center0 个研究点目标入组 102 人开始时间: 待定最近更新: 2020年9月7日

适应症

试验速览

暂无简介。

•1.Diagnosis of delirium using Korean version of CAM-ICU or by intensivists using Intensive Care Delirium Screening checklist (ICDSC)
•2.Age =18 years and = 90 years
•3.Glasgow Coma Score (GCS): 9-15
•4.Operation or non-operation cases
•5.Expected ICU stay > 48 hours

•6.Safety concerns with drug administration: Heart rate <50 beats/minute, known preoperative left ventricular ejection fraction less than 30%, 2° or greater AV block in the absence of a pacemaker, sick sinus syndrome, torsades de pointes, prolonged corrected QT (> 550 ms) from the baseline EKG
•7.History of severe dementia, schizophrenia, Parkinsonism, or myasthenia gravis
•8.Current treatment with dexmedetomidine or clonidine
•9.Dexmedetomidine or antipsychotics (quetiapine or haloperidol) allergic history
•10.Post-anoxic coma; status epilepticus without underlying brain injury; central nervous system (CNS) infections (community-acquired; hospital-acquired; ventriculitis; post-operative)
•11.History of hepatic encephalopathy or end stage liver disease (Child- Pugh Class B or C)
•12.Pregnancy or Nephrotic syndrome diagnosed patient
•13.Brain death or imminent death (within 24 hours)
•14.DNR (do not resuscitate) orders

发起方