KCT0005367
Recruiting
未知
Delirium in Acute Neurocritical Patient; Comparative Efficacy of Dexmedetomidine vs. Antipsychotics (Quetiapine and Haloperidol)
ConditionsMental and behavioral disorders
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Mental and behavioral disorders
- Sponsor
- Asan Medical Center
- Enrollment
- 102
- Status
- Recruiting
- Last Updated
- 5 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\.Diagnosis of delirium using Korean version of CAM\-ICU or by intensivists using Intensive Care Delirium Screening checklist (ICDSC)
- •2\.Age \=18 years and \= 90 years
- •3\.Glasgow Coma Score (GCS): 9\-15
- •4\.Operation or non\-operation cases
- •5\.Expected ICU stay \> 48 hours
Exclusion Criteria
- •6\.Safety concerns with drug administration: Heart rate \<50 beats/minute, known preoperative left ventricular ejection fraction less than 30%, 2° or greater AV block in the absence of a pacemaker, sick sinus syndrome, torsades de pointes, prolonged corrected QT (\> 550 ms) from the baseline EKG
- •7\.History of severe dementia, schizophrenia, Parkinsonism, or myasthenia gravis
- •8\.Current treatment with dexmedetomidine or clonidine
- •9\.Dexmedetomidine or antipsychotics (quetiapine or haloperidol) allergic history
- •10\.Post\-anoxic coma; status epilepticus without underlying brain injury; central nervous system (CNS) infections (community\-acquired; hospital\-acquired; ventriculitis; post\-operative)
- •11\.History of hepatic encephalopathy or end stage liver disease (Child\- Pugh Class B or C)
- •12\.Pregnancy or Nephrotic syndrome diagnosed patient
- •13\.Brain death or imminent death (within 24 hours)
- •14\.DNR (do not resuscitate) orders
Outcomes
Primary Outcomes
Not specified
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