The effect of experimental hyperglycemia and AT1 receptor blockade on renal hemodynamics in impaired glucose tolerance
Completed
- Conditions
- Impaired glucose tolerance/ renal changes in prediabetesNutritional, Metabolic, Endocrine
- Registration Number
- ISRCTN07427212
- Lead Sponsor
- Technical University of Munich (Germany)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Male
- Target Recruitment
- 24
Inclusion Criteria
1. Males
2. 18-70 years old
3. Impaired Glucose Tolerance (for the intervention group [IGT-Group]) (tested by the oral glucose tolerance test according to the World Health Organisation) and normoglycemic patients (for control group [healthy subjects])
Exclusion Criteria
1. Renal or liver insufficiency
2. Micro-or macro-albuminuria
3. Overt diabetes mellitus
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The following were measured at rest (U1 rest, U2 rest) and during hyperglycemic stress testing (U1 stress, U2 stress) with and without AT1 receptor blocker treatment:<br>1. Glomerular filtration rate (inulin clearance) <br>2. Renal plasma flow (Para-AminoHippurate [PAH] clearance) <br><br>U1: Without AT1 receptor blocker<br>U2: After a 4-week treatment with valsartan
- Secondary Outcome Measures
Name Time Method The following were assessed at U1 and U2: <br>1. High-sensitivity C-Reactive Protein (CRP) <br>2. Adiponectin <br>3. HbA1c (blood tests) <br><br>U1: Without AT1 receptor blocker <br>U2: After a 4-week treatment with valsartan