Comparison of Aqueous Humor Adipokines in Glaucoma Patients and Healthy Controls

Recruiting

• Conditions: Glaucoma; Adipokines
• Interventions: Other: none intervention

• Registration Number: NCT06190119
• Lead Sponsor: Peking University

Brief Summary

The purpose of this study is to observe whether there are differences in adipokines in the aqueous humor between patients with primary open-angle glaucoma (POAG) and healthy controls

Detailed Description

1. Inclusion criteria: Patients aged 18 years or older, diagnosed with primary open-angle glaucoma (POAG) and healthy controls (who underwent cataract surgery).

2. Exclusion criteria:

1. Other Ocular Diseases: Patients with concurrent ocular diseases such as macular degeneration, retinal detachment, etc., are excluded.

2. Ocular Surgery History: individuals who have undergone intraocular or laser surgery within the past 6 months, except for uncomplicated cataract surgery.

3. History of Ocular Trauma or Inflammation

4. Systemic Diseases or Mental Disorders: Patients with systemic diseases(e.g., diabetes, rheumatoid arthritis) and those with mental disorders are excluded.

5. Pregnancy or Lactation: Females who are pregnant or lactating are excluded.

6. Presence of any retinal or optic nerve disease other than glaucoma.

Study Timeline

• Study Start: 2023-10-08
• Status Verified: 2023-12
• Study First Submitted: 2023-12-19
• Study First Submitted QC: 2023-12-19
• Last Update Submitted: 2023-12-19
• Primary Completion: 2023-12-31
• Study First Posted: 2024-01-05
• Last Update Posted: 2024-01-05
• Study Completion: 2024-04-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 2

Inclusion Criteria

• Patients aged 18 years or older, diagnosed with primary open-angle glaucoma (POAG) and healthy controls (who underwent cataract surgery).

Exclusion Criteria

• Other Ocular Diseases: Patients with concurrent ocular diseases such as macular degeneration, retinal detachment, etc., are excluded.
• Ocular Surgery History: individuals who have undergone intraocular or laser surgery within the past 6 months, except for uncomplicated cataract surgery.
• History of Ocular Trauma or Inflammation
• Systemic Diseases or Mental Disorders: Patients with systemic diseases(e.g., diabetes, rheumatoid arthritis) and those with mental disorders are excluded.
• Pregnancy or Lactation: Females who are pregnant or lactating are excluded.
• Presence of any retinal or optic nerve disease other than glaucoma.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Control Group	none intervention	Healthy patients who underwent cataract surgery.
POAG Group	none intervention	POAG patients who underwent filtering surgery, cataract surgery or MIGS.

Primary Outcome Measures

Name	Time	Method
Concentration of adipokines in aqueous humor	Cross-sectional baseline	Aqueous humor samples were assessed for adipokines and inflammatory cytokines by Luminex bead-based multiplex array

Trial Locations

Locations (1)

Peking University Third Hosipital; 🇨🇳 Beijing, Beijing, China