Combined perfusion MRI and MR spectroscopy in multiple sclerosis
- Conditions
- multiple sclerosis10012303
- Registration Number
- NL-OMON30006
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 60
Inclusioncriteria patients:
- age 18-60 years
- diagnosis of multiple sclerosis according to the McDonald-criteria (McDonald et al., 2001).
- written informed consent;Inclusioncriteria controls:
- age eightteen and older
- written informed consent
Exclusioncriteria patients:
- use of systemic corticosteroids in the eight weeks before start of the study
- use of immunomodulating therapies (interferon-ß, glatiramer acetate)
- a history of cerebral pathology other than MS (brain infarct, brain haemorrhage, Parkinson's disease, Alzheimer's disease, cerebral vasculitis, brain absces)
- Diabetes mellitus;Exclusiecriteria controls:
- a history of cerebral pathology (brain infarct, brain haemorrhage, Parkinson's disease, Alzheimer's disease, cerebral vasculitis, brain absces)
- Diabetes mellitus
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Primary endpoints:<br /><br>- The difference in measures of cerebral perfusion between the groups of RRMS,<br /><br>SPMS, PPMS patients and healthy controls.<br /><br>- The difference in measures of cerebral metabolism (as measured with MR<br /><br>spectroscopy) between the groups of RRMS, SPMS, PPMS patients and healthy<br /><br>controls.<br /><br>- The correlation between measures of cerebral perfusion and cerebral<br /><br>metabolism in the groups RRMS, SPMS, PPMS and healthy control persons.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary endpoints:<br /><br>- the correlation between clinical measures of disability with measures of<br /><br>cerebral perfusion<br /><br>- the correlation of clinical measures of disability with measures of cerebral<br /><br>metabolism</p><br>
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.