Opioid Use After Traumatic Injury in Adolescents

Completed

• Conditions: Opioid Use; Traumatic Injury; Substance Abuse Disorder; Adolescent Behavior

• Registration Number: NCT03628846
• Lead Sponsor: Indiana University

Brief Summary

Currently, 1 in 8 adolescents continue to receive prescription opioids a year or more after injury. By longitudinally surveying patients, we can identify risk factors and pathways to nonmedical opioid use. Furthermore, by assessing whether pain management and mental health treatment after injury moderates sustained opioid use and prescription opioid misuse, we can create targeted interventions to reduce future nonmedical opioid use in adolescents.

Detailed Description

This is a prospective cohort study that will follow participants for 2 years and administer surveys to adolescents both traumatically injured and uninjured on prescription opioid usage, substance use, utilization of pain management and mental health services, and mental and physical health condition conditions.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2018-07-01
• Study First Submitted: 2018-08-09
• Study First Submitted QC: 2018-08-09
• Study First Posted: 2018-08-14
• Primary Completion: 2023-03-31
• Study Completion: 2023-04-30
• Status Verified: 2023-05
• Last Update Submitted: 2023-05-18
• Last Update Posted: 2023-05-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 123

Inclusion Criteria

• Patient is 12-20 years of age
• Adolescent admitted for trauma OR adolescent with no recent trauma
• English speaking
• Consent can be obtained from a parent or guardian

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Exclusion Criteria

• Patients with severe brain injuries or other injuries that prevent survey participation

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prospectively determine drivers of sustained opioid use and prescription opioid misuse.	2 years

Secondary Outcome Measures

Name	Time	Method
Identify patient-reported factors for sustained prescription opioid use, including chronic pain and mental health conditions such as PTSD, depression, anxiety, and sleep disorders.	2 years
Assess behavioral, social, and clinical predictors of prescription opioid misuse and nonmedical opioid use by longitudinally surveying injured adolescents.	2 years
Qualitatively determine patients' motives for continued opioid therapy, prescription opioid misuse, and nonmedical opioid use by interviewing injured adolescents.	2 years
Analyze genetic information, obtained via saliva sample and the company 23andMe, from each participant to determine if some people are more likely to use more pain medication than others or respond better to certain pain medications.	2 years

Trial Locations

Locations (1)

Indiana University; 🇺🇸 Indianapolis, Indiana, United States