The effect of treatment of neonatal electrographic seizures, detected with the continuous cerebral function monitoring, with respect to occurrence of postneonatal epilepsy and neurodevelopmental outcome.

Completed

• Conditions: eonatal seizures; Pregnancy and Childbirth; Neonatal seizures

• Registration Number: ISRCTN61541169
• Lead Sponsor: niversity Medical Centre Utrecht (UMCU) (Netherlands)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2005-12-20
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

Full term infants admitted to the neonatal intensive care unit, within the first 24 hours after birth with subclinical seizures on the aEEG, in 8 Dutch and 3 Belgium centres.

Exclusion Criteria

1. Preterm infants (less than 37 weeks Gestational Age [GA]) and full term infants with neonatal seizures admitted after the first 24 hours after birth
2. Infants with chromosomal disorders, congenital anomalies and meningitis

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. What is the number of electrographic seizure discharges missed if you do not monitor continuously<br>2. Does instantaneous treatment of electrographical seizures lead to:<br>2.1. A reduction of seizure discharges <br>2.2. Less damage on the neonatal Magnetic Resonance Imaging (MRI)

Secondary Outcome Measures

Name	Time	Method
Does treatment of neonatal seizures lead to a reduced risk of Post-Neonatal Epilepsy (PNE) and an improved neurodevelopmental outcome at 24 months.