impact of tranexamic acid on the prevention of during and post-caesarean hemorrhage

Not Applicable

• Conditions: Haematological Disorders; Pregnancy and Childbirth; Surgery; post partum hemorhage

• Registration Number: PACTR202108668389918
• Lead Sponsor: niversity Hospital Lamine Debaghine Bab El Oued

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-08-17
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 796

Inclusion Criteria

- Scheduled or semi-emergency cesarean section.
- Live fetus.
- Gestational age greater than or equal to 35 SA.
- Parturients classified as ASA I or ??,consenting, with 2 or more risk factors for postpartum hemorrhage:
* polyhydramnios.
* age greater than 35 years.
* Fetal macrosomia.
* coagulation anomaly.
* thrombopenia.
* anticoagulant treatment.
* antecedents of postpartum hemorrhage.
* placenta pravea not recovering.
* Anemia.
* Pre-eclampsia.
* Multiple pregnancy.
* Multiple pregnancy.
* Chorioamniotitis.

Exclusion Criteria

- Allergy to tranexamic acid.
- Severe renal impairment.
- History of thrombosis.
- Epilepsy.
- Death in utero
- Severe medical or surgical complication involving the heart, liver, kidneys, or brain.
- Placental insertion anomalies: placenta accreta and covering pravea.
- Caesarean sections performed for active bleeding during uterine rupture, retro placental hematoma, or placenta previa.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
There was statistically significant reduction in the mean blood loss among the study group<br>who received tranexamique acid in comparison to the control group

Secondary Outcome Measures

Name	Time	Method
no major side effects