Multi-omics Analysis of Chronic Kidney Disease
- Conditions
- Potential Mechanisms Underlying the Microbiota-Gut-Kidney Axis in CKD
- Registration Number
- NCT05543291
- Lead Sponsor
- Shanghai 10th People's Hospital
- Brief Summary
Chronic kidney disease (CKD) is a progressive disease with hidden epidemics and one of the most significant contributing factors to end-stage renal disease (ESRD), cardiovascular comorbidities, cachexia and anemia, which accounts for a nearly 1.2 million populations died per year.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 150
Age-matched and gender-matched HC with normal renal and liver function and not taking any medications were enrolled
- Age<18 years.
- Individuals with hypertension, diabetes, obesity, metabolic syndrome or pregnancy.
- Individuals who received gastrointestinal operation, antibiotics or probiotic products within one month.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Functional and structural alteration of microbiotas and their crosstalk with CKD-associated metabolism baseline Gut metagenome, fecal metabolome and serum metabolome were performed in this disease-severity classified CKD cohort, to identify the changes of microbial compositions and metabolism in CKD progression
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Department of Nephrolgoy, Shanghai 10th People's Hospital
🇨🇳Shanghai, Shanghai, China
Department of Nephrolgoy, Shanghai 10th People's Hospital🇨🇳Shanghai, Shanghai, ChinaAi Peng, Ph.D., M.D.Contact86-21-66302524pengai@hotmail.com