Multi-omics Analysis of Chronic Kidney Disease

Shanghai 10th People's Hospital1 site in 1 country150 target enrollmentJanuary 1, 2022

ConditionsPotential Mechanisms Underlying the Microbiota-Gut-Kidney Axis in CKD

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Potential Mechanisms Underlying the Microbiota-Gut-Kidney Axis in CKD
Sponsor: Shanghai 10th People's Hospital
Enrollment: 150
Locations: 1
Primary Endpoint: Functional and structural alteration of microbiotas and their crosstalk with CKD-associated metabolism
Status: Recruiting
Last Updated: 3 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Chronic kidney disease (CKD) is a progressive disease with hidden epidemics and one of the most significant contributing factors to end-stage renal disease (ESRD), cardiovascular comorbidities, cachexia and anemia, which accounts for a nearly 1.2 million populations died per year.

Registry

clinicaltrials.gov

Start Date

January 1, 2022

End Date

December 31, 2024

Last Updated

3 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Shanghai 10th People's Hospital

Responsible Party

Principal Investigator

Ai Peng

Shanghai tenth People's Hospital

Shanghai 10th People's Hospital

Eligibility Criteria

Inclusion Criteria

•Age-matched and gender-matched HC with normal renal and liver function and not taking any medications were enrolled

Exclusion Criteria

•Age\<18 years.
•Individuals with hypertension, diabetes, obesity, metabolic syndrome or pregnancy.
•Individuals who received gastrointestinal operation, antibiotics or probiotic products within one month.

Outcomes

Primary Outcomes

Functional and structural alteration of microbiotas and their crosstalk with CKD-associated metabolism

Time Frame: baseline

Gut metagenome, fecal metabolome and serum metabolome were performed in this disease-severity classified CKD cohort, to identify the changes of microbial compositions and metabolism in CKD progression