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Multi-omics Analysis of Chronic Kidney Disease

Recruiting
Conditions
Potential Mechanisms Underlying the Microbiota-Gut-Kidney Axis in CKD
Registration Number
NCT05543291
Lead Sponsor
Shanghai 10th People's Hospital
Brief Summary

Chronic kidney disease (CKD) is a progressive disease with hidden epidemics and one of the most significant contributing factors to end-stage renal disease (ESRD), cardiovascular comorbidities, cachexia and anemia, which accounts for a nearly 1.2 million populations died per year.

Detailed Description

Not available

Recruitment & Eligibility

Status
RECRUITING
Sex
All
Target Recruitment
150
Inclusion Criteria

Age-matched and gender-matched HC with normal renal and liver function and not taking any medications were enrolled

Exclusion Criteria
  1. Age<18 years.
  2. Individuals with hypertension, diabetes, obesity, metabolic syndrome or pregnancy.
  3. Individuals who received gastrointestinal operation, antibiotics or probiotic products within one month.

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Functional and structural alteration of microbiotas and their crosstalk with CKD-associated metabolismbaseline

Gut metagenome, fecal metabolome and serum metabolome were performed in this disease-severity classified CKD cohort, to identify the changes of microbial compositions and metabolism in CKD progression

Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (1)

Department of Nephrolgoy, Shanghai 10th People's Hospital

🇨🇳

Shanghai, Shanghai, China

Department of Nephrolgoy, Shanghai 10th People's Hospital
🇨🇳Shanghai, Shanghai, China
Ai Peng, Ph.D., M.D.
Contact
86-21-66302524
pengai@hotmail.com

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