To find out echocardiographic (use of ultrasound to investigate the actions of heart) parameter to say which can develop post reperfusion syndrome (complication that may develop during organ transplant) during liver transplant.

Recruiting

• Conditions: Liver disorders in diseases classified elsewhere, (2) ICD-10 Condition: K746||Other and unspecified cirrhosis ofliver,

• Registration Number: CTRI/2022/03/041168
• Lead Sponsor: Institute of liver and biliary sciences

Brief Summary

Patients undergoing liver transplant frequently display considerable physiological changes during the procedures as a result of both the disease process and the surgery. Haemodynamic changes occurring during liver transplantation are severe and rapid. Transoesophageal echocardiography is a minimally invasive monitor that provides real-time visual information regarding dynamic function of heart, volume status, contractility, regional wall motion. Intraoperative transoesophageal echocardiography has been standard practice for cardiac surgical procedures for more than 2 decades but its use during liver transplant is gaining popularity in recent years. Society for advancement of transplant anesthesia suggests, that transoesophageal echocardiography use in liver transplant recipients is effective and safe.1 Vital information which can be gathered from standard transoesophageal echocardiography views includes biventricular function, valvular function, volume status, pericardial abnormalities, intra-cardiac thrombus, pulmonary embolism, ventricular outflow obstruction, cardiac tamponade.

As per our literature search, intraoperative transesophageal echocardiographic parameters have never been studied to predict the post reperfusion syndrome during living donor liver transplantation. Hence, we are conducting this study to find the intraoperative transesophageal echocardiographic parameters which can predict the post reperfusion syndrome during living donor liver transplantation.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-03-24
• Last Update Posted: 2022-04-09

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

All patients undergoing LDLT in whom transesophageal echocardiography probe will be inserted Age > 18 years.

Exclusion Criteria

• Patient refusal Patients undergoing double transplant at same setting.
• Patients with Acute Liver Failure Previous history of oesophageal pathology (esophageal stricture, cancer, diverticulum, laceration, > grade 3 oesophageal varices, Gastric varices, active esophagitis) or recent esophageal surgery.
• History of recent (< 1 month) upper gastro-intestinal bleed.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Transesophageal echocardiographic parameter to predict post reperfusion syndrome during living donor liver transplantation	Baseline after induction | 10 minutes after reperfusion | After abdominal closure

Secondary Outcome Measures

Name	Time	Method
Transesophageal echocardiographic parameter to predict time to achieve hemodynamic stability	Baseline after induction

Trial Locations

Locations (1)

Institute of liver and biliary sciences; 🇮🇳 Delhi, DELHI, India

Institute of liver and biliary sciences

🇮🇳Delhi, DELHI, India

Dr Vaishali Agarwal

Principal investigator

8840661695

shagun30agarwal@gmail.com