NCT00551434已完成不适用
Effect of Creatine and L-Arginine on Endothelial Function in Patients With Coronary Artery Disease
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 119
- 主要终点
- Brachial artery flow-mediated dilation
研究概览
简要总结
The study is a double blind 2x2 factorial study. Patients with coronary disease will be randomly be assigned to L-arginine (9 g/day), creatine 21 g/d, both, or neither dietary supplement. The function of the endothelium will be tested using ultrasound before and after each treatment. These studies will help us understand why the endothelium is abnormal in patients with coronary artery disease and how L-arginine is acting on endothelial function.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Coronary artery disease
排除标准
- •Pregnancy
- •Creatine use within one month of study
- •L-arginine use within one month of study
- •Change in dose or initiation of lipid lowering therapy, aspirin therapy, or angiotensin converting enzyme therapy within one month of study
结局指标
主要结局
Brachial artery flow-mediated dilation
时间窗: 5 days
次要结局
- serum arginine, creatine, creatinine, homocysteine(5 days)
研究者
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