Randomized open controlled clinical study to evaluate the efficacy of tuvari lepa in the management of mukhdushika(yuvan pidika) with special reference to acne vulgaris
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- Marked improvement
研究概览
简要总结
The skin is unique in many ways, but no other organ demands so much attention and concern in both states of disease and health. There is huge focus on skin health, with fierce competition to have glowing, clearer, healthier, younger and fresher skin.
Appearance is important in our society and influences the way in which we are perceived by others. The skin is the most visible organ of the body and determines, to a large extent, our appearance, with a wide function in social and sexual communication. 1
Skin diseases have a negative impact on human beings, both in acceptance of their own image and in quality of life. 2
Mukhdushika is one of various skin diseases explained in Ayurveda. This is a very common disease in adolescence, so it is called as Yuvan pidika.
शालà¥à¤®à¤²à¥€à¤•à¤‚टक पà¥à¤°à¤–à¥à¤¯à¤¾ कफ मारà¥à¤¤ शोणितै:
जायनà¥à¤¤à¥‡ पिडका यà¥à¤¨à¤¾à¤‚ विजà¥à¤žà¥‡à¤¯à¤¾ यां मà¥à¤–दà¥à¤·à¤¿à¤•à¤¾ (सà¥.नि.१३/३९) 3
In mukhdushika there is a kapha, vata, rakta dushti which leads to elevations like shalmali thorn. Mukhdushika is a shudra rog, as described by Acharya Sushruta in Nidan sthana 13 and chikitsa sthana 20 under kshudra rog.
In Ayurveda, acne vulgaris is corelated with mukhdushika or yuvan pidika under the heading of kshudrarog described by Sushruta. 4
Acharya Sharangdhar has mentioned yuvan pidika (Acne Vulgaris) as the mala (waste) of shukra dhatu (semen) along with vaktra snigdhata. Shukra pradurbhava (release of shukra dhatu) takes Acne is chronic inflammation of the pilosebaceous units. It is a extremely common condition, it generally starts after puberty and there are reports of it affecting over 90% of adolescents. 6
As Ayurvedic medicines are very much effective in such skin diseases so the subject has been chosen.
研究设计
- 研究类型
- Interventional
- 分配方式
- Adaptive randomization, such as minimization
- 盲法
- Open Label
入排标准
- 年龄范围
- 12.00 Year(s) 至 32.00 Year(s)（—）
入选标准
- •Patients having age between 12 years to 32 years are included.
- •Patient diagnosed with mukhdushika
- •Patients who are not on any treatment of mukhdushika since 1 week.
排除标准
- •Patients having age below 12 years and above 30 years Patients having another chronic skin diseases Patients already on treatment mukhdushika.
结局指标
主要结局
Marked improvement
时间窗: At baseline 7th day , 15th day,30th day
Moderate improvement
时间窗: At baseline 7th day , 15th day,30th day
Unchanged
时间窗: At baseline 7th day , 15th day,30th day
Slight improvement
时间窗: At baseline 7th day , 15th day,30th day
次要结局
- Reduced the acne,pain and swelling(At baseline 7th day, 15th day , 30th day)