Effectiveness of Artificial Saliva plus Beta-Glucan for Treatment of Xerostomia in Older Adults
Phase 4
Completed
- Conditions
- Older adults with xerostomia for at least a week.Xerostomia, Artificial saliva, Beta-glucan, antioxidant, Moisturizing effect, Total Antioxidant Capacity.
- Registration Number
- TCTR20230206008
- Lead Sponsor
- Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 51
Inclusion Criteria
1.Subjects age older than 60 years old
2.Subjects that have experienced subjective feelings of dry mouth for more than 7 days
Exclusion Criteria
1)Subjects have previous radiation therapy (head and neck area)
2)Subjects have previous chemotherapy
3)Subjects have cancer or tumor of the salivary gland.
4)Subjects have a history of systemic diseases explaining the diminished salivary flow (i.e., Sjogren syndrome, infection of the salivary glands,)
5) Pregnant or breastfeeding women
6) Decompensated systemic disorders or cognitive problems.
7)Subjects have immunodeficiency diseases
8)Subjects who are allergic to fungal or yeast
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Xerostomia Inventory (XI) 4 weeks Xerostomia Inventory (XI) score
- Secondary Outcome Measures
Name Time Method Clinical oral dryness score (CODS) 4 weeks Clinical oral dryness score (CODS) (0-10),Oral moisture degree in patients with dry mouth measure by oral moisture checking device 4 weeks scale(0-99.9),The whole unstimulated saliva flow rate 4 weeks ml/min,Salivary total antioxidant capacity 4 weeks Salivary TAC,Evaluation of post-use satisfaction with artificial saliva spray 4 weeks Satisfaction score(1-5)