An Observational Study to Collect and Assess Tissue Samples From Subjects With One of Three Neoplastic Conditions (ANSWer)
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Acute Myelogenous Leukemia
- Sponsor
- Notable Labs
- Enrollment
- 119
- Locations
- 20
- Primary Endpoint
- Clinical response to treatment
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
This is a prospective, multicenter observational study to collect clinically annotated biospecimens in order to assess the correlation between ex vivo data generated by the Notable assay platform and clinical outcome.
Detailed Description
This is a prospective, multicenter, observational study with collection of de-identified biospecimens with matched clinical data from up to 1000 participants from clinical networks in the United States and Canada. Clinical information, demographics, and medical data relevant to cancer status are collected from all participants and their medical record at baseline (at study entry and time of baseline biospecimen collection), and subsequent visits per patient consent, for up to 1 year. The primary assessment is the establishment of a tumor registry with annotated clinical outcomes. Exploratory assessments include correlation of ex vivo functional testing results with clinical outcomes, as well as identification of potential biomarkers that correlate responses with genotype and/or phenotype.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Provide written informed consent;
- •Age ≥ 18 years, male or female, of any race;
- •Documented hematologic malignancy (any of the below) in need of starting an active anti-cancer therapy:
- •Acute myelogenous leukemia (AML)
- •Multiple myeloma (MM)
- •Myelodysplastic syndrome (MDS)
- •Acute lymphocytic leukemia (ALL)
- •Chronic lymphocytic leukemia (CLL)
- •Chronic myelogenous leukemia (CML)
- •Neoplasm (MPN)
Exclusion Criteria
- •Unwilling or unable to give consent
- •Subject's disease is in remission
- •Subject cohort is not open at time of consent
- •Subject is restarting an ongoing treatment regimen after a dose interruption
Outcomes
Primary Outcomes
Clinical response to treatment
Time Frame: 3 years
Collect clinical responses to treatment and outcomes in patients who have provided samples to the biobank
Secondary Outcomes
- Type of clinical treatment responses(3 years)
- Types of somatic tumor mutations(3 years)