TCTR20220430005尚未招募4 期
Effect of combined Vitamin C and B1 vs. vitamin C alone on inflammatory response in patients who undergoing valvular surgery.
Faculty of medicine, Prince of Songkla University0 个研究点目标入组 64 人开始时间: 2022年4月30日最近更新:
适应症
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 64
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 Years 至 N/A (No limit)（—）
- 性别
- All
入选标准
- •1. Scheduled for elective non-emergent valve repair or replacement
- •2. Aged 18 years or older
- •3. Left ventricular ejection fraction > 35%
- •4. No known coagulopathy prior to surgery
排除标准
- •1. Administration of vitamin C and/or B1 in the previous 7 days
- •2. Known allergy to thiamine (B1) and vitamin C
- •3. Competing indication for thiamine administration as judged by the clinical team (e.g., alcoholic)
- •4. Research-protected populations (pregnant women, prisoners, the intellectually disabled)
- •5. Emergency cardiac surgery
- •6. Ejection fraction no less than 35%
- •7. Presence of autoimmune disease or currently receiving immunosuppressant therapy
- •8. History of renal calculi or urolithiasis
- •9. Patients who iron deficiency (e.g.,thalassemia, hemochromatosis)
- •10. Renal dysfunction (pre-operative creatinine clearance < 40 mL/min, or serum creatinine greater than 1.8 mg/dl)
- •11. known bleeding diathesis such as hemophilia, Von Willebrand's disease, or liver failure, or receiving concurrent anticoagulant therapy (such as warfarin, dabigatran, or apixaban) for venous or arterial thrombosis
- •12. Active infection, cancer, or tumor
- •13. Prior history of atrial fibrillation
- •14. Prisoner
- •15. Pregnancy
- •16. On mechanical ventilation on the day of surgery
- •17. Need vasopressor/inotropic agents on the day of surgery
研究者
相似试验
招募中
3 期
Assessing the effect of vitamin B1 and vitamin C on treatment of sever sepsisIRCT20210518051339N1Esfahan University of Medical Sciences86
已完成
不适用
The effect vitamin C supplementation on infertile women with polycystic ovary syndromeIRCT2013030312672N1Shiraz University Of Medical Sciences56
招募中
不适用
Effect of daily vitamin C supplementation with or without flavonoid supplements on periodontal and systemic conditions before and after periodontal treatmentperiodontitisNL-OMON46353niversiteit van Amsterdam81
尚未招募
不适用
The effect of flavonoids and vitamin C on periodontitisPeriodontitis - ParodontitisVitamin C - Vitamine CFlavanoids - FlavonoidenQuercetin - QuercetineNL-OMON22290Academic Centre for Dentistry Amsterdam (ACTA)University of Amsterdam (UVA) and Vrije Universiteit (VU) AmsterdamGustav Mahlerlaan 3004, 1081 LA AmsterdamThe Netherlands81
已完成
3 期
Effect of dextromethorphan and vit c in postoperative pain in abdominal surgeryAbdominal post operative pain.Other abdominal painR10.8IRCT20230612058463N1Islamic Azad University150