NCT03027349已完成不适用
Serum Calcium to Phosphorous Ratio (Ca/P) as a Simple, Inexpensive Screening Tool in the Diagnosis of Primary Hyperparathyroidism
Azienda USL Modena1 个研究点 分布在 1 个国家目标入组 180 人开始时间: 2011年1月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 180
- 试验地点
- 1
- 主要终点
- Calcium
研究概览
简要总结
Background:
Primary hyperparathyroidism (PHPT) is often overlooked and underdiagnosed. At present the diagnosis of PHPT remains challenging and is based on serum calcium (Ca) and PTH.
As serum Ca and phosphorous (P) are inversely related in PHPT, the Ca/P ratio might be considered a good candidate tool in the diagnosis of PHPT.
AIM: The aim of this study is to investigate the diagnostic value of the Ca/P ratio in the diagnosis of PHPT.
Study design: Retrospective, observational, cross-sectional, case-control clinical trial will be carried out.
Biochemical measurements will include PTH, Vitamin D, serum Ca, P, albumin, and creatinine.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •elevated parathormone serum levels
- •normal or elevated calcium serum levels
排除标准
- •age younger than 18 years
- •renal and liver failure and insufficiency
- •active metabolic bone disease (such as Paget's disease of the bone, osteomalacia, rickets, etc)
- •any type of cancer
- •malnutrition, severe obesity (BMI > 40 kg/m2) and malabsorption
- •transplantation
- •sarcoidosis
- •endocrinological disorders such as hypercortisolism, diabetes insipidus, hyperthyroidism, pseudohypoparathyroidism
- •familial hypocalciuric hypercalcemia
- •hypophosphoremia sustained by genetic causes or secondary to other causes.
结局指标
主要结局
Calcium
时间窗: Enrollment time
Assay performed at the moment of diagnosis
次要结局
- Creatinine(Enrollment time)
- Albumine(Enrollment time)
- Phosphorus(Enrollment time)
- Parathormone(Enrollment time)
- Vitamin D(Enrollment time)
研究者
Manuela Simoni
Director
Azienda USL Modena
研究点 (1)
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