Dietary Restrictions Implications on Metabolic Changes in Obese Men : Comparison Between Two Groups of Different Ages (60-70 Years Old Versus 30-40 Years Old)
概览
- 阶段
- 不适用
- 干预措施
- dietary restrictions
- 疾病 / 适应症
- Obesity
- 发起方
- University Hospital, Toulouse
- 入组人数
- 71
- 试验地点
- 2
- 主要终点
- Lipolysis at resting and during physical activity test
- 状态
- 已完成
- 最后更新
- 23天前
概览
简要总结
The prevalence of obesity is growing in elderly with heavy consequences in term of medical complications and mortality, so that this is nowadays an important public health issue.
The major therapeutic solution is dietary restrictions, but and the advantages and the metabolic consequences are not well known in elderly. The MONA study main aim is to assess the metabolic changes in this population, after dietary restrictions, compared to young people.
详细描述
Primary endpoint : Study the metabolic adaptations of the subcutaneous adipose tissue after a diet in elderly obese men compared to young obese men. Secondary endpoints : Study the metabolic adaptations of skeletal muscle, the genetic adaptations of subcutaneous adipose tissue and skeletal muscle, the inflammatory and fibrosis modifications of subcutaneous adipose tissue, the insulinosensibility modifications, the modifications on the physical composition, modifications of the energy expenditure in resting state and the oxidation of the substrata, study the lipoproteins metabolism and identify new biomarkers. All those endpoints are studied comparing elderly obese subjects versus young obese subjects.
研究者
入排标准
入选标准
- •30 \< years old \< 40 OR 60 \< years old \< 70
- •obesity : 30 \< BMI \< 40
- •stable blood pressure (diastolic \<90mmHg, systolic \< 140mmHg)
- •glycemia \< 1,26g/L, LDL cholest \<1,9-1,6g/L, Triglycerides \<2,5g/L
- •risk factors concerning high blood pressure, diabetes and dyslipidemia under control
排除标准
- •Insulin dependent diabetes, non-insulin dependent diabetes
- •high blood pressure
- •dyslipidemia
- •history of cardiovascular diseases or bariatric surgery
- •undernutrition
- •HbA1C \>7%
- •non authorized treatments : Glucagon-like peptide-1 agonists,
- •incapacity to do physical activity
研究组 & 干预措施
obese men from 60 to 70 years old
Dietary restrictions in obese men (30\<Body Mass Index\<40 kg/m2)
干预措施: dietary restrictions
obese men from 30 to 40 years old
Dietary restrictions in obese men (30\<Body Mass Index\<40 kg/m2)
干预措施: dietary restrictions
结局指标
主要结局
Lipolysis at resting and during physical activity test
时间窗: Change after 8 weeks dietary restrictions
Determine lipolysis at resting and during physical activity test by microdialysis, before dietary restrictions and after dietary restrictions (20% dietary restrictions)
次要结局
- Metabolic parameters in skeletal muscle(Change after 8 weeks dietary restrictions)
- Genetic markers(Change after 8 weeks dietary restrictions)
- insulinosensibility(Change after 8 weeks dietary restrictions)
- Fibrosis and inflammatory markers in adipose tissue(Change after 8 weeks dietary restrictions)
- Fat and muscles rates in the whole body(Change after 8 weeks dietary restrictions)
- Lipoproteins metabolism(Change after 8 weeks dietary restrictions)
- biomarkers identification(Change after 8 weeks dietary restrictions)
- Energetic consumption(Change after 8 weeks dietary restrictions)