The Second Affiliated Hospital of Hainan Medical University

Primary endpoint:

· Overall response rate (ORR) : It refers to the proportion of patients whose tumor volume reduction reaches the pre-specified value and can maintain the minimum time requirement, which is a Complete Response (CR) and a partial response (PR). Partial Response) sum of the proportions.

Secondary points:

• Progression-free Survival (PFS) : the time from the start of treatment until objective tumor Progression or all-cause death of the patient.
• Disease Control Rate (DCR) : The percentage of patients whose cancer shrinks or remains stable over time.
• Overall Survival (OS) : the time from the start of treatment to all-cause death.
• Incidence of adverse reactions: toxicity according to Common Toxicity Criteria for Adverse Events (CTCAE).
• Quality of life: The EORTC Quality of Life measure -QLQ-C30-(V3.0) was used, and the higher the score, the higher the quality of life.
• Dosimetric parameters： include gross target volume（GTV）， clinical target volume（CTV），internal target volume(ITV),planning target volume（PTV），γ-passing rate，and limited dose of organs at risk (including average dose, maximum dose, etc.)