Effect of Normal Aging on Language Processing
- Conditions
- Cognition
- Registration Number
- NCT02189460
- Lead Sponsor
- University Hospital, Grenoble
- Brief Summary
The purpose of this study is to understand the effect of age on language abilities. The investigators aim at investigating the cerebral modifications that take place in normal aging, at the functional an anatomical level.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 33
- Age of 30 years and above
- Right handed
- French native speakers
- Affiliation to French social security (Sécurité Sociale)
- Medical interview
- Consent form signed
- Cerebral or respiratory pathologies
- Any MRI contrindication
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Blood Oxygen Level Dependent functional MRI There will be a unique MRI measurement for each participant. Group analyses presentation after 1 year. We use 3 functional tasks using block paradigm: Object naming, Verbal generation and semantic judgment, to elicit BOLD response using fMRI in order to compare functional activation patterns between subjects.
We also use hypercapnic challenge to elicit BOLD response in order to obtain Cerebral Vascular Reactivity properties of subjects.Anatomical MRI There will be a unique MRI measurement for each participant. Group analyses presentation after 1 year. We use Voxel Based Morphometry to compare cortical volume (grey matter) between subjects.
We also use tractography Diffusion Tensor Imaging to compare white matter properties between subjects.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
IRMaGe facility
🇫🇷Grenoble, France