Effect of unilateral conductive hearing loss and its therapy on neuronal activity of the auditory sys-tem – a PET, MRI/DMI, fNIRS and microphenomenologic study

Not Applicable

Conditions: H90.1
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side

Registration Number: DRKS00033812

Lead Sponsor: niklinik Freiburg

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 160

Inclusion Criteria

Study group 1:
- Diagnosis with unilateral conductive hearing loss
- Treatment with a bone-conductive device or an active middle ear implant
Study group 2:
- Diagnosis with unilateral conductive hearing loss
- No treatment with a bone-conductive device or an active middle ear implant
Study group 1 and 2:
- age = 18 years
- right handed
- German at at least B1 level

Exclusion Criteria

- Relevant neurological or psychiatric illness
- Circumstances and illnesses that suggest insufficient compliance with the PET or fMRI examination
- Pregnancy, breastfeeding
- Poorly controlled diabetes mellitus
- Study-related radiation exposure from previous study participation
- Relevant ophthalmological diseases
- Participants do not agree to the communication of incidental findings.

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Study groups 1 und 2:<br>Neuronal activity of the auditory cortex during acoustic, visual and vibrotactil stimulation (fNRIS, functional near-infrared spectroscopy)

Secondary Outcome Measures

Name	Time	Method
Study group 1<br>- Glucose uptake in the primary auditory coretx and inferior colliculus<br>- interhemispheric connectivity of the primary auditory coretx