Mitochondrial Dysfunction and Oxidative Stress in Chronic Obstructive Pulmonary Disease (COPD) Patients
Not Applicable
Completed
- Conditions
- COPD Patients
- Interventions
- Other: Training
- Registration Number
- NCT01183052
- Lead Sponsor
- 5 Santé
- Brief Summary
The purpose of this study is to understand the underlying mechanisms of improved exercise tolerance in COPD patients after training program.
- Detailed Description
Training protocol used is based on recommendations (Nici et al., 2006) and was previously used in our group (Varray et al., 1991; Vallet et al., 1997). A minimum of 20 sessions in 4-6 weeks were proposed. The exercise intensity of exercise corresponds to target heart rate at ventilatory threshold measured during incremental exercise test. Training at this intensity allowed us to individualize effort for each patient.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
- Sedentary mild to severe COPD patients
Exclusion Criteria
- Neuromuscular disease
- Chronic heart failure
- Renal diseases
- Liver diseases
- Obesity
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Training Training 20 sessions of training
- Primary Outcome Measures
Name Time Method Cellular effects of exercise training at the ventilatory threshold intensity 6 to 8 weeks
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
Clinique du Souffle la Solane
🇫🇷Osseja, France
Clinique du Souffle La Vallonie
🇫🇷Lodeve, France