NCT01183052
Completed
Not Applicable
Mitochondrial Respiratory Chain and Peripheral Muscle Dysfunction in COPD Patients
5 Santé2 sites in 1 country30 target enrollmentJune 2009
ConditionsCOPD Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- COPD Patients
- Sponsor
- 5 Santé
- Enrollment
- 30
- Locations
- 2
- Primary Endpoint
- Cellular effects of exercise training at the ventilatory threshold intensity
- Status
- Completed
- Last Updated
- 13 years ago
Overview
Brief Summary
The purpose of this study is to understand the underlying mechanisms of improved exercise tolerance in COPD patients after training program.
Detailed Description
Training protocol used is based on recommendations (Nici et al., 2006) and was previously used in our group (Varray et al., 1991; Vallet et al., 1997). A minimum of 20 sessions in 4-6 weeks were proposed. The exercise intensity of exercise corresponds to target heart rate at ventilatory threshold measured during incremental exercise test. Training at this intensity allowed us to individualize effort for each patient.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Sedentary mild to severe COPD patients
Exclusion Criteria
- •Neuromuscular disease
- •Chronic heart failure
- •Renal diseases
- •Liver diseases
Outcomes
Primary Outcomes
Cellular effects of exercise training at the ventilatory threshold intensity
Time Frame: 6 to 8 weeks
Study Sites (2)
Loading locations...
Similar Trials
Completed
Not Applicable
Role of Mitochondrial-derived Oxidative Stress to Promote Vascular Endothelial Dysfunction in Non-exercisers With AgingAgingEndothelial DysfunctionCardiovascular FunctionArterial StiffnessNCT05872139Ball State University23
Active, not recruiting
Not Applicable
Target Mitochondrial Fitness, Chronobiology and MetabolismHealthy SubjectsNCT05600192Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud100
Completed
Not Applicable
Effects of Exercise-intensity on Physiological Adaptations in Overweight and ObeseOverweightObesityNCT01453972Norwegian University of Science and Technology30
Completed
Not Applicable
Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin ResistanceMitochondrial MyopathiesMitochondrial DiseasesMitochondrial DisordersNCT06080594Rigshospitalet, Denmark11
Terminated
Not Applicable
Mitochondrial Respiratory Function in Mammalian Skeletal MuscleCancerCachexiaNCT02650570The University of Texas Medical Branch, Galveston1