Pancreatic Stone Protein as Indicator for Urinary Sepsis in Intensive Care Units
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 80
- 主要终点
- PSP ability to detect urinary sepsis
研究概览
简要总结
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. For clinical operationalization, organ dysfunction can be represented by an increase in the Sequential Organ Failure Assessment (SOFA) score of 2 points or more, which is associated with an in-hospital mortality greater than 10%. pancreatic stone protein has been studied as biomarker of sepsis and results suggests that it has higher diagnostic performance. The main objective of this study is to identify ability of pancreatic stone protein (PSP) as a new biomarker for diagnosis of urosepsis in Intensive Care Units comparison to other biomarkers and its role as a prognostic marker for mortality
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult ill patients at the ICU aged more than 18 years old who at risk of urosepsis.
- •Both males and females.
排除标准
- •- Age less than 18 years.
- •Patients with a clinical diagnosis of sepsis at admission.
- •Critically ill septic patients with a diagnosis other than urosepsis.
- •Critically ill patients who were diagnosed to have urosepsis outside Ain Shams university intensive care and transferred to it.
- •Malignant tumor patients.
- •Uremic patients undergoing dialysis.
结局指标
主要结局
PSP ability to detect urinary sepsis
时间窗: measurements from admission and patients will be followed until death or discharge from or for 30 days whichever occurred the ICU
time course of PSP serum levels above normal range 20-50ng/ml in absence or presence of infection.
次要结局
- PSP ability to predict prognosis of sepsis in ICU.(measurements from admission and patients will be followed until death or discharge from or for 30 days whichever occurred the ICU)
研究者
Mohamed Sayed Maamoun Ibraheem
Doctor
Ain Shams University